2. MAPK/ERK Pathway
  3. MAP3K
  4. TAK1-IN-3

TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor.

For research use only. We do not sell to patients.

TAK1-IN-3 Chemical Structure

TAK1-IN-3 Chemical Structure

CAS No. : 494772-87-1

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

TAK1-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All MAP3K Isoform Specific Products:

View All Isoforms
MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

  • Biological Activity

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Description

TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor.

IC50 & Target

TAK1

 

Molecular Weight

317.41

Formula

C16H19N3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(N)C=C(C2=CC=C(CN3CCOCC3)C=C2)S1)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (315.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1505 mL 15.7525 mL 31.5050 mL
5 mM 0.6301 mL 3.1505 mL 6.3010 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1505 mL 15.7525 mL 31.5050 mL 78.7625 mL
5 mM 0.6301 mL 3.1505 mL 6.3010 mL 15.7525 mL
10 mM 0.3150 mL 1.5752 mL 3.1505 mL 7.8762 mL
15 mM 0.2100 mL 1.0502 mL 2.1003 mL 5.2508 mL
20 mM 0.1575 mL 0.7876 mL 1.5752 mL 3.9381 mL
25 mM 0.1260 mL 0.6301 mL 1.2602 mL 3.1505 mL
30 mM 0.1050 mL 0.5251 mL 1.0502 mL 2.6254 mL
40 mM 0.0788 mL 0.3938 mL 0.7876 mL 1.9691 mL
50 mM 0.0630 mL 0.3150 mL 0.6301 mL 1.5752 mL
60 mM 0.0525 mL 0.2625 mL 0.5251 mL 1.3127 mL
80 mM 0.0394 mL 0.1969 mL 0.3938 mL 0.9845 mL
100 mM 0.0315 mL 0.1575 mL 0.3150 mL 0.7876 mL
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TAK1-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAK1-IN-3494772-87-1MAP3KMAP kinase kinase kinase, MEKK, MAPKKKInhibitorinhibitorinhibit

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