2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tau-aggregation and neuroinflammation-IN-1

Tau-aggregation and neuroinflammation-IN-1 

Cat. No.: HY-146005 Purity: 99.97%
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Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats.

For research use only. We do not sell to patients.

Tau-aggregation and neuroinflammation-IN-1 Chemical Structure

Tau-aggregation and neuroinflammation-IN-1 Chemical Structure

CAS No. : 2175953-98-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 51 In-stock
Solution
10 mM * 1 mL in DMSO USD 51 In-stock
Solid
5 mg USD 50 In-stock
10 mg USD 80 In-stock
25 mg USD 150 In-stock
50 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

Tau-aggregation and neuroinflammation-IN-1 Related Antibodies

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Description

Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats[1].

IC50 & Target

AcPHF6, tau-aggregation, NO[1]
In Vitro

Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM, and exerts no significant hepatotoxicity in LO2 cells at high concentrations, also exerts no effect on BV2 cell viability at 20 μM[1].
Tau-aggregation and neuroinflammation-IN-1 (2.5, 5 and 10 μM; 24 hours) retains the anti-inflammatory activity of sodium usnate and inhibits NO release rate by 41% in LPS-stimulated BV2 cells at 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tau-aggregation and neuroinflammation-IN-1 Related Antibodies

Cell Cytotoxicity Assay

Cell Line: SH-SY5Y, LO2 and BV-2 cells[1]
Concentration: 0, 10, 20, 30 and 40 μM
Incubation Time: 24 hours
Result: Reduced the survival of SH-SY5Y cells at 30 μM, and exerted no significant hepatotoxicity in LO2 cells even at high concentrations (up to 40 μM), also exerted no effect on BV2 cell viability at 20 μM.
In Vivo

Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; for 14 days) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SD rats (250-270 g; OA was microinjected into the right dorsal hippocampus)[1]
Dosage: 5 and 10 mg/kg
Administration: IP; for 7 days, and after OA-injection continued IP for 7 days
Result: Led to a substantial improvement of the conventional reference spatial memory and cognitive abilities of rats.
Molecular Weight

460.44

Formula

C25H20N2O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(N2N=C(C)C3=C2C=C(OC4=C(C(C)=O)C(O)=C(C)C(O)=C45)[C@]5(C)C3=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (271.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1718 mL 10.8592 mL 21.7184 mL
5 mM 0.4344 mL 2.1718 mL 4.3437 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.97%

COA (258 KB) HNMR (264 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1718 mL 10.8592 mL 21.7184 mL 54.2959 mL
5 mM 0.4344 mL 2.1718 mL 4.3437 mL 10.8592 mL
10 mM 0.2172 mL 1.0859 mL 2.1718 mL 5.4296 mL
15 mM 0.1448 mL 0.7239 mL 1.4479 mL 3.6197 mL
20 mM 0.1086 mL 0.5430 mL 1.0859 mL 2.7148 mL
25 mM 0.0869 mL 0.4344 mL 0.8687 mL 2.1718 mL
30 mM 0.0724 mL 0.3620 mL 0.7239 mL 1.8099 mL
40 mM 0.0543 mL 0.2715 mL 0.5430 mL 1.3574 mL
50 mM 0.0434 mL 0.2172 mL 0.4344 mL 1.0859 mL
60 mM 0.0362 mL 0.1810 mL 0.3620 mL 0.9049 mL
80 mM 0.0271 mL 0.1357 mL 0.2715 mL 0.6787 mL
100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5430 mL
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Tau-aggregation and neuroinflammation-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tau-aggregation and neuroinflammation-IN-12175953-98-5Microtubule/TubulinUsnic acid derivativesAlzheimer’s diseaseTau anti-aggregationAnti-inflammatoryInhibitorinhibitorinhibit

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