2. Autophagy Metabolic Enzyme/Protease
  3. Autophagy Endogenous Metabolite
  4. Taurine

Taurine  (Synonyms: 2-Aminoethanesulfonic acid)

Cat. No.: HY-B0351 Purity: 99.88%
SDS COA Handling Instructions

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Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.

For research use only. We do not sell to patients.

Taurine Chemical Structure

Taurine Chemical Structure

CAS No. : 107-35-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
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10 mM * 1 mL in Water USD 55 In-stock
Solid
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5 g USD 72 In-stock
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Based on 7 publication(s) in Google Scholar

Other Forms of Taurine:

Taurine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
10 μM
Compound: 1123
Substrate uptake by the Taurine Transporter (TauT, SLC6A6) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A6 cells
Substrate uptake by the Taurine Transporter (TauT, SLC6A6) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A6 cells
10.5281/zenodo.7360560
L6 IC50
> 90 μg/mL
Compound: 6
Cytotoxicity against rat L6 cells after 72 hrs
Cytotoxicity against rat L6 cells after 72 hrs
[PMID: 17765547]
In Vitro

Taurine is one of the most abundant amino acids in the brain and spinal cord, leukocytes, heart and muscle cells, the retina, and indeed almost every tissue throughout the body[1].
Taurine exhibits diverse biological actions, including protection against ischemia-reperfusion injury, modulation of intracellular calcium concentration, and antioxidant, antiatherogenic and blood pressure-lowering effects[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Taurine Related Antibodies
Clinical Trial
Molecular Weight

125.15

Formula

C2H7NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCS(=O)(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (199.76 mM; Need ultrasonic)

DMSO : 1 mg/mL (7.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.9904 mL 39.9521 mL 79.9041 mL
5 mM 1.5981 mL 7.9904 mL 15.9808 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 12.5 mg/mL (99.88 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.88%

SDS (393 KB)

COA (246 KB) HNMR (108 KB) RP-HPLC (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 7.9904 mL 39.9521 mL 79.9041 mL 199.7603 mL
5 mM 1.5981 mL 7.9904 mL 15.9808 mL 39.9521 mL
H2O 10 mM 0.7990 mL 3.9952 mL 7.9904 mL 19.9760 mL
15 mM 0.5327 mL 2.6635 mL 5.3269 mL 13.3174 mL
20 mM 0.3995 mL 1.9976 mL 3.9952 mL 9.9880 mL
25 mM 0.3196 mL 1.5981 mL 3.1962 mL 7.9904 mL
30 mM 0.2663 mL 1.3317 mL 2.6635 mL 6.6587 mL
40 mM 0.1998 mL 0.9988 mL 1.9976 mL 4.9940 mL
50 mM 0.1598 mL 0.7990 mL 1.5981 mL 3.9952 mL
60 mM 0.1332 mL 0.6659 mL 1.3317 mL 3.3293 mL
80 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4970 mL
100 mM 0.0799 mL 0.3995 mL 0.7990 mL 1.9976 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Taurine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taurine107-35-72-Aminoethanesulfonic acidAutophagyEndogenous Metaboliteantioxidantantiatherogenicbloodpressure-loweringcardiovascularbilesaltsInhibitorinhibitorinhibit

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