2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. TCJL37

TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD).

For research use only. We do not sell to patients.

TCJL37 Chemical Structure

TCJL37 Chemical Structure

CAS No. : 1258294-34-6

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5 mg USD 485 In-stock
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Based on 1 publication(s) in Google Scholar

TCJL37 Related Antibodies

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JAK1 JAK2 JAK3 Tyk2 JAK

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TCJL37 is a potent, selective, and orally bioavailable TYK2 inhibitor with a Ki of 1.6 nM. TCJL37 can be used for the research of inflammatory bowel diseases (IBD)[1].

IC50 & Target[1]

Tyk2

1.6 nM (Ki)

In Vitro

In cell-based assays, TCJL37 (Compound 37) shows IL-12 pSTAT4 EC50 of 224 nM. TCJL37 shows EC50s of 168 nM and 737 nM In human peripheral blood mononuclear cells (PBMC) and human whole blood assay, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TCJL37 Related Antibodies
In Vivo

TCJL37 exhibits excellent oral exposure in CD-1 mice following oral administration (100 mg/kg). TCJL37 exhibits low clearance (1.0 mL/min/kg) in rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

376.74

Formula

C17H11ClF2N4O2
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=CC(NC([C@@H]2[C@H](F)C2)=O)=NC=C1)C3=C(F)C=C(C#N)C=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (663.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6544 mL 13.2718 mL 26.5435 mL
5 mM 0.5309 mL 2.6544 mL 5.3087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.89%

COA (246 KB) HNMR (260 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6544 mL 13.2718 mL 26.5435 mL 66.3588 mL
5 mM 0.5309 mL 2.6544 mL 5.3087 mL 13.2718 mL
10 mM 0.2654 mL 1.3272 mL 2.6544 mL 6.6359 mL
15 mM 0.1770 mL 0.8848 mL 1.7696 mL 4.4239 mL
20 mM 0.1327 mL 0.6636 mL 1.3272 mL 3.3179 mL
25 mM 0.1062 mL 0.5309 mL 1.0617 mL 2.6544 mL
30 mM 0.0885 mL 0.4424 mL 0.8848 mL 2.2120 mL
40 mM 0.0664 mL 0.3318 mL 0.6636 mL 1.6590 mL
50 mM 0.0531 mL 0.2654 mL 0.5309 mL 1.3272 mL
60 mM 0.0442 mL 0.2212 mL 0.4424 mL 1.1060 mL
80 mM 0.0332 mL 0.1659 mL 0.3318 mL 0.8295 mL
100 mM 0.0265 mL 0.1327 mL 0.2654 mL 0.6636 mL
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TCJL37 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCJL371258294-34-6TCJL 37TCJL-37JAKJanus kinaseTYK2inflammatoryboweldiseasesIBDInhibitorinhibitorinhibit

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