2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Drug Metabolite Reactive Oxygen Species
  4. Tetrachlorohydroquinone

Tetrachlorohydroquinone  (Synonyms: TCHQ; Tetrachloroquinol)

Cat. No.: HY-W144308 Purity: 98.45%
SDS COA Handling Instructions

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Tetrachlorohydroquinone (TCHQ) is a metabolite of pentachlorophenol. Tetrachlorohydroquinone increases DNA lesions and induce oxidative stress in rodents.

For research use only. We do not sell to patients.

Tetrachlorohydroquinone Chemical Structure

Tetrachlorohydroquinone Chemical Structure

CAS No. : 87-87-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
1 g USD 50 Get quote
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Tetrachlorohydroquinone Related Antibodies

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  • Purity & Documentation

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Description

Tetrachlorohydroquinone (TCHQ) is a metabolite of pentachlorophenol. Tetrachlorohydroquinone increases DNA lesions and induce oxidative stress in rodents[1].

Molecular Weight

247.89

Formula

C6H2Cl4O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

C1(=C(C(=C(C(=C1Cl)O)Cl)Cl)O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (806.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0340 mL 20.1702 mL 40.3405 mL
5 mM 0.8068 mL 4.0340 mL 8.0681 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (20.17 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.45%

SDS (393 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0340 mL 20.1702 mL 40.3405 mL 100.8512 mL
5 mM 0.8068 mL 4.0340 mL 8.0681 mL 20.1702 mL
10 mM 0.4034 mL 2.0170 mL 4.0340 mL 10.0851 mL
15 mM 0.2689 mL 1.3447 mL 2.6894 mL 6.7234 mL
20 mM 0.2017 mL 1.0085 mL 2.0170 mL 5.0426 mL
25 mM 0.1614 mL 0.8068 mL 1.6136 mL 4.0340 mL
30 mM 0.1345 mL 0.6723 mL 1.3447 mL 3.3617 mL
40 mM 0.1009 mL 0.5043 mL 1.0085 mL 2.5213 mL
50 mM 0.0807 mL 0.4034 mL 0.8068 mL 2.0170 mL
60 mM 0.0672 mL 0.3362 mL 0.6723 mL 1.6809 mL
80 mM 0.0504 mL 0.2521 mL 0.5043 mL 1.2606 mL
100 mM 0.0403 mL 0.2017 mL 0.4034 mL 1.0085 mL
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Tetrachlorohydroquinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrachlorohydroquinone87-87-6TCHQ TetrachloroquinolDrug MetaboliteReactive Oxygen SpeciesRTL-W1HepG2fish cellInhibitorinhibitorinhibit

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