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  4. Tetrahydroxydiboron

Tetrahydroxydiboron  (Synonyms: Hypodiboric acid)

Cat. No.: HY-W004761 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Tetrahydroxydiboron can be used to optimize the Miyaura borylation process, replacing bis(pinacolato) diboron by hydrolyzing the resulting boronic ester to its corresponding acid.

For research use only. We do not sell to patients.

Tetrahydroxydiboron Chemical Structure

Tetrahydroxydiboron Chemical Structure

CAS No. : 13675-18-8

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Tetrahydroxydiboron Related Antibodies

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Description

Tetrahydroxydiboron can be used to optimize the Miyaura borylation process, replacing bis(pinacolato) diboron by hydrolyzing the resulting boronic ester to its corresponding acid[1].

Molecular Weight

89.65

Formula

B2H4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OB(O)B(O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (1115.45 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.1545 mL 55.7724 mL 111.5449 mL
5 mM 2.2309 mL 11.1545 mL 22.3090 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (27.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (27.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

COA (247 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 11.1545 mL 55.7724 mL 111.5449 mL 278.8622 mL
5 mM 2.2309 mL 11.1545 mL 22.3090 mL 55.7724 mL
10 mM 1.1154 mL 5.5772 mL 11.1545 mL 27.8862 mL
15 mM 0.7436 mL 3.7182 mL 7.4363 mL 18.5908 mL
20 mM 0.5577 mL 2.7886 mL 5.5772 mL 13.9431 mL
25 mM 0.4462 mL 2.2309 mL 4.4618 mL 11.1545 mL
30 mM 0.3718 mL 1.8591 mL 3.7182 mL 9.2954 mL
40 mM 0.2789 mL 1.3943 mL 2.7886 mL 6.9716 mL
50 mM 0.2231 mL 1.1154 mL 2.2309 mL 5.5772 mL
60 mM 0.1859 mL 0.9295 mL 1.8591 mL 4.6477 mL
80 mM 0.1394 mL 0.6972 mL 1.3943 mL 3.4858 mL
100 mM 0.1115 mL 0.5577 mL 1.1154 mL 2.7886 mL
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Tetrahydroxydiboron Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydroxydiboron13675-18-8Hypodiboric acidBiochemical Assay ReagentsMiyaura borylation processInhibitorinhibitorinhibit

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