TNFα activity modulator 3

Cat. No.: HY-160412 Purity: 98.30%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TNFα activity modulator 3 (example 6) is a modulator of TNF activity that inhibits TNFα-induced NF-κB activation and can be utilized in relevant research.

For research use only. We do not sell to patients.

TNFα activity modulator 3 Chemical Structure

CAS No. : 2248726-53-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 354	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 354	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1040	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1660	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

TNFα activity modulator 3 (example 6) is a modulator of TNF activity that inhibits TNFα-induced NF-κB activation and can be utilized in relevant research^[1].

Molecular Weight

502.52

Formula

C₂₇H₂₄F₂N₆O₂

CAS No.

2248726-53-4

Appearance

Solid

Color

White to off-white

SMILES

FC(F)OC1=C(C(C2=O)=CC=C1)[C@](C[C@@]3([H])N2C)([H])N4C3=NC5=CC=C(C6=CN=C(C7(CCC7)N)N=C6)C=C45

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 116.67 mg/mL (232.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9900 mL	9.9499 mL	19.8997 mL
5 mM	0.3980 mL	1.9900 mL	3.9799 mL
10 mM	0.1990 mL	0.9950 mL	1.9900 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.30%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (259 KB) HNMR (276 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Daniel C, et al. Fused pentacyclic imidazole derivatives as modulators of tnf activity, WO2018197503A1, 2018-11-01

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9900 mL	9.9499 mL	19.8997 mL	49.7493 mL
	5 mM	0.3980 mL	1.9900 mL	3.9799 mL	9.9499 mL
	10 mM	0.1990 mL	0.9950 mL	1.9900 mL	4.9749 mL
	15 mM	0.1327 mL	0.6633 mL	1.3266 mL	3.3166 mL
	20 mM	0.0995 mL	0.4975 mL	0.9950 mL	2.4875 mL
	25 mM	0.0796 mL	0.3980 mL	0.7960 mL	1.9900 mL
	30 mM	0.0663 mL	0.3317 mL	0.6633 mL	1.6583 mL
	40 mM	0.0497 mL	0.2487 mL	0.4975 mL	1.2437 mL
	50 mM	0.0398 mL	0.1990 mL	0.3980 mL	0.9950 mL
	60 mM	0.0332 mL	0.1658 mL	0.3317 mL	0.8292 mL
	80 mM	0.0249 mL	0.1244 mL	0.2487 mL	0.6219 mL
	100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.4975 mL