2. NF-κB
  3. NF-κB
  4. TNFα activity modulator 3

TNFα activity modulator 3 (example 6) is a modulator of TNF activity that inhibits TNFα-induced NF-κB activation and can be utilized in relevant research.

For research use only. We do not sell to patients.

TNFα activity modulator 3 Chemical Structure

TNFα activity modulator 3 Chemical Structure

CAS No. : 2248726-53-4

Size Price Stock Quantity
5 mg USD 320 In-stock
10 mg USD 520 In-stock
25 mg USD 1040 In-stock
50 mg USD 1660 In-stock
100 mg USD 2650 In-stock
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Based on 1 publication(s) in Google Scholar

TNFα activity modulator 3 Related Antibodies

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Description

TNFα activity modulator 3 (example 6) is a modulator of TNF activity that inhibits TNFα-induced NF-κB activation and can be utilized in relevant research[1].

Molecular Weight

502.52

Formula

C27H24F2N6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)OC1=C(C(C2=O)=CC=C1)[C@](C[C@@]3([H])N2C)([H])N4C3=NC5=CC=C(C6=CN=C(C7(CCC7)N)N=C6)C=C45
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (232.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9900 mL 9.9499 mL 19.8997 mL
5 mM 0.3980 mL 1.9900 mL 3.9799 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9900 mL 9.9499 mL 19.8997 mL 49.7493 mL
5 mM 0.3980 mL 1.9900 mL 3.9799 mL 9.9499 mL
10 mM 0.1990 mL 0.9950 mL 1.9900 mL 4.9749 mL
15 mM 0.1327 mL 0.6633 mL 1.3266 mL 3.3166 mL
20 mM 0.0995 mL 0.4975 mL 0.9950 mL 2.4875 mL
25 mM 0.0796 mL 0.3980 mL 0.7960 mL 1.9900 mL
30 mM 0.0663 mL 0.3317 mL 0.6633 mL 1.6583 mL
40 mM 0.0497 mL 0.2487 mL 0.4975 mL 1.2437 mL
50 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9950 mL
60 mM 0.0332 mL 0.1658 mL 0.3317 mL 0.8292 mL
80 mM 0.0249 mL 0.1244 mL 0.2487 mL 0.6219 mL
100 mM 0.0199 mL 0.0995 mL 0.1990 mL 0.4975 mL
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TNFα activity modulator 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNFα activity modulator 32248726-53-4TNFα activity modulator3TNFα activity modulator-3NF-κBNuclear factor-κBNuclear factor-kappaBTNFαautoimmuneinflammatory disorderscardiovascular disordersmetabolic disordersoncological disordersInhibitorinhibitorinhibit

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