(Trifluoromethyl)trimethylsilane

Name: (Trifluoromethyl)trimethylsilane
Brand: MedChemExpress
SKU: HY-Y0147
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y0147 Purity: ≥98.0%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Trimethylsilyl(trifluoromethyl)silane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

(Trifluoromethyl)trimethylsilane Chemical Structure

CAS No. : 81290-20-2

Size	Price	Stock	Quantity
5 g	USD 30	In-stock	Estimated Time of Arrival: April 21
10 g	USD 45	In-stock	Estimated Time of Arrival: April 21
25 g	USD 77	In-stock	Estimated Time of Arrival: April 21
50 g	USD 108	In-stock	Estimated Time of Arrival: April 21
100 g	USD 152	In-stock	Estimated Time of Arrival: April 21
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Biological Activity
Purity & Documentation
Customer Review

Description

Trimethylsilyl(trifluoromethyl)silane is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

(Trifluoromethyl)trimethylsilane is employed as a valuable reagent for trifluoromethylation of electrophilic substrates. It is also use an the nucleophilic addition of the trifluoromethyl group to aldehydes and ketones. It generates trifluoromethyl with catalytic amounts of F-(TBAF or CsF ) and reacts with carbonyl compounds to produce trifluoromethylated alcohols.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

142.20

Formula

C₄H₉F₃Si

CAS No.

81290-20-2

Appearance

Liquid (Density: 0.962 g/cm³)

Color

Colorless to light yellow

SMILES

FC([Si](C)(C)C)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (703.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0323 mL	35.1617 mL	70.3235 mL
5 mM	1.4065 mL	7.0323 mL	14.0647 mL
10 mM	0.7032 mL	3.5162 mL	7.0323 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (17.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (243 KB) SDS (466 KB)

COA (244 KB) HNMR (208 KB) CNMR (221 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.0323 mL	35.1617 mL	70.3235 mL	175.8087 mL
	5 mM	1.4065 mL	7.0323 mL	14.0647 mL	35.1617 mL
	10 mM	0.7032 mL	3.5162 mL	7.0323 mL	17.5809 mL
	15 mM	0.4688 mL	2.3441 mL	4.6882 mL	11.7206 mL
	20 mM	0.3516 mL	1.7581 mL	3.5162 mL	8.7904 mL
	25 mM	0.2813 mL	1.4065 mL	2.8129 mL	7.0323 mL
	30 mM	0.2344 mL	1.1721 mL	2.3441 mL	5.8603 mL
	40 mM	0.1758 mL	0.8790 mL	1.7581 mL	4.3952 mL
	50 mM	0.1406 mL	0.7032 mL	1.4065 mL	3.5162 mL
	60 mM	0.1172 mL	0.5860 mL	1.1721 mL	2.9301 mL
	80 mM	0.0879 mL	0.4395 mL	0.8790 mL	2.1976 mL
	100 mM	0.0703 mL	0.3516 mL	0.7032 mL	1.7581 mL