2. Protein Tyrosine Kinase/RTK Neuronal Signaling TGF-beta/Smad Stem Cell/Wnt JAK/STAT Signaling Epigenetics Immunology/Inflammation
  3. Src CaMK PKA EGFR PKC COX
  4. TX-1123

TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.

For research use only. We do not sell to patients.

TX-1123 Chemical Structure

TX-1123 Chemical Structure

CAS No. : 157397-06-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

TX-1123 Related Antibodies

Top Publications Citing Use of Products

View All Src Isoform Specific Products:

View All Isoforms
Lck Fyn Blk

View All CaMK Isoform Specific Products:

View All Isoforms
CaMK III CaMK II

View All PKA Isoform Specific Products:

View All Isoforms
PKA PKAR

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All PKC Isoform Specific Products:

View All Isoforms
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

View All COX Isoform Specific Products:

View All Isoforms
COX COX-1 COX-2 COX-3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer[1][2].

IC50 & Target[2]

COX-2

1.16 nM (IC50)

COX-1

15.7 μM (IC50)

In Vitro

TX-1123 (NIH3T3 cells) inhibits Src-K, eEF2-K, PKA, PKC, EGFR-k with IC50 values of 2.2, 3.2, 9.6, 320, and 320 μM, respectively[1].
TX-1123 (mitochondrial suspension) has a weaker mitochondrial toxicity and ATP-synthesis inhibitory activities with an IC50 value of 5 μM[1].
TX-1123 (0-1000 μM; 48 h) has antitumor activity with IC50 values of 3.66, 39, and 57 μM for HepG2, HCT116, and Rat hepatocytes, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TX-1123 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2, HCT116, and Rat hepatocytes
Concentration: 0-1000 μM
Incubation Time: 48 hours
Result: Inhibited tumor cell growth in a dose-dependent manner.
Molecular Weight

312.40

Formula

C20H24O3
CAS No.
SMILES

O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TX-1123 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX-1123157397-06-3TX1123TX 1123SrcCaMKPKAEGFRPKCCOXCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesProtein kinase AEpidermal growth factor receptorErbB-1HER1Protein kinase CCyclooxygenaseprotein tyrosine kinasecancerNIH3T3 cellsmitochondrialtoxicityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TX-1123
Cat. No.:
HY-121828
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.