2. Anti-infection
  3. Bacterial Fungal
  4. Chlorobutanol

Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry.

For research use only. We do not sell to patients.

Chlorobutanol Chemical Structure

Chlorobutanol Chemical Structure

CAS No. : 57-15-8

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chlorobutanol:

Chlorobutanol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry[1][2][3][4].

In Vitro

Chlorobutanol (25-100 mg/mL, 4 min) has no influence on the static sensitivity of the muscle spindle endings and the axon membrane[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorobutanol Related Antibodies
In Vivo

Chlorobutanol (62.5-250 mg/kg, oral gavage, daily for 2 weeks) shows clinical signs in this animal included severe ataxia, dyspnea, and a moribund state in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (age 6 weeks)[4]
Dosage: 62.5-250 mg/kg
Administration: oral gavage, daily for 2 weeks
Result: Significantly decreased the body weight in rats.
Animal Model: Rats (age 6 weeks)[4]
Dosage: 12.5-100 mg/kg
Administration: oral gavage, daily for 4 weeks
Result: Showed an unusual form and significant lesions in the organs and tubular hyaline droplets in rats.
Molecular Weight

177.46

Formula

C4H7Cl3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(O)(C)C(Cl)(Cl)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (563.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6351 mL 28.1754 mL 56.3507 mL
5 mM 1.1270 mL 5.6351 mL 11.2701 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (14.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (14.09 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

COA (247 KB) HNMR (115 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6351 mL 28.1754 mL 56.3507 mL 140.8768 mL
5 mM 1.1270 mL 5.6351 mL 11.2701 mL 28.1754 mL
10 mM 0.5635 mL 2.8175 mL 5.6351 mL 14.0877 mL
15 mM 0.3757 mL 1.8784 mL 3.7567 mL 9.3918 mL
20 mM 0.2818 mL 1.4088 mL 2.8175 mL 7.0438 mL
25 mM 0.2254 mL 1.1270 mL 2.2540 mL 5.6351 mL
30 mM 0.1878 mL 0.9392 mL 1.8784 mL 4.6959 mL
40 mM 0.1409 mL 0.7044 mL 1.4088 mL 3.5219 mL
50 mM 0.1127 mL 0.5635 mL 1.1270 mL 2.8175 mL
60 mM 0.0939 mL 0.4696 mL 0.9392 mL 2.3479 mL
80 mM 0.0704 mL 0.3522 mL 0.7044 mL 1.7610 mL
100 mM 0.0564 mL 0.2818 mL 0.5635 mL 1.4088 mL
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Chlorobutanol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorobutanol57-15-8BacterialFungalorally activeplatelet aggregationantibacterial activitypreservativethromboxane B2ATP releasefree calciumGram-positiveInhibitorinhibitorinhibit

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