Chlorobutanol

Name: Chlorobutanol
Brand: MedChemExpress
SKU: HY-B1263
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1263 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry.

For research use only. We do not sell to patients.

Chlorobutanol Chemical Structure

CAS No. : 57-15-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
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500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Chlorobutanol:

Chlorobutanol hemihydrate Get quote
Chlorobutanol (Standard) Get quote

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Description

In Vitro

Chlorobutanol (25-100 mg/mL, 4 min) has no influence on the static sensitivity of the muscle spindle endings and the axon membrane^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chlorobutanol (62.5-250 mg/kg, oral gavage, daily for 2 weeks) shows clinical signs in this animal included severe ataxia, dyspnea, and a moribund state in rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats (age 6 weeks)^[4]
Dosage:	62.5-250 mg/kg
Administration:	oral gavage, daily for 2 weeks
Result:	Significantly decreased the body weight in rats.

Animal Model:	Rats (age 6 weeks)^[4]
Dosage:	12.5-100 mg/kg
Administration:	oral gavage, daily for 4 weeks
Result:	Showed an unusual form and significant lesions in the organs and tubular hyaline droplets in rats.

Molecular Weight

177.46

Formula

C₄H₇Cl₃O

CAS No.

57-15-8

Appearance

Solid

Color

White to off-white

SMILES

CC(O)(C)C(Cl)(Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (563.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6351 mL	28.1754 mL	56.3507 mL
5 mM	1.1270 mL	5.6351 mL	11.2701 mL
10 mM	0.5635 mL	2.8175 mL	5.6351 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (14.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (247 KB) HNMR (115 KB)

Handling Instructions (2659 KB)

References

[1]. Smoak IW, et al. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997 Oct;39(5):287-90. [Content Brief]

[2]. Chen SL, et al. Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. Thromb Haemost. 1990 Nov 30;64(3):473-7. [Content Brief]

[3]. Fischer M. Effects of chlorobutanol on primary and secondary endings of isolated cat muscle spindles. Brain Res. 2000 Jan 31;854(1-2):106-21. [Content Brief]

[4]. Jeong D, et al. In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol. Toxics. 2022 Jan 7;10(1):24. [Content Brief]

[5]. Friesen WT, et al. The antibacterial stability of chlorobutanol stored in polyethylene bottles. Am J Hosp Pharm. 1971 Jul;28(7):507-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.6351 mL	28.1754 mL	56.3507 mL	140.8768 mL
	5 mM	1.1270 mL	5.6351 mL	11.2701 mL	28.1754 mL
	10 mM	0.5635 mL	2.8175 mL	5.6351 mL	14.0877 mL
	15 mM	0.3757 mL	1.8784 mL	3.7567 mL	9.3918 mL
	20 mM	0.2818 mL	1.4088 mL	2.8175 mL	7.0438 mL
	25 mM	0.2254 mL	1.1270 mL	2.2540 mL	5.6351 mL
	30 mM	0.1878 mL	0.9392 mL	1.8784 mL	4.6959 mL
	40 mM	0.1409 mL	0.7044 mL	1.4088 mL	3.5219 mL
	50 mM	0.1127 mL	0.5635 mL	1.1270 mL	2.8175 mL
	60 mM	0.0939 mL	0.4696 mL	0.9392 mL	2.3479 mL
	80 mM	0.0704 mL	0.3522 mL	0.7044 mL	1.7610 mL
	100 mM	0.0564 mL	0.2818 mL	0.5635 mL	1.4088 mL

Chlorobutanol Related Classifications

Neurological Disease Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chlorobutanol57-15-8BacterialFungalorally activeplatelet aggregationantibacterial activitypreservativethromboxane B2ATP releasefree calciumGram-positiveInhibitorinhibitorinhibit

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Chlorobutanol

Customer Review

Other Forms of Chlorobutanol:

Chlorobutanol Related Antibodies

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Chlorobutanol Related Antibodies

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Complete Stock Solution Preparation Table

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