2. Anti-infection
  3. Parasite
  4. Umifoxolaner

Umifoxolaner  (Synonyms: ML-878)

Cat. No.: HY-139587 Purity: 99.97%
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Umifoxolaner is an anti-parasitic agent (veterinary).

For research use only. We do not sell to patients.

Umifoxolaner Chemical Structure

Umifoxolaner Chemical Structure

CAS No. : 2021230-37-3

Size Price Stock Quantity
1 mg USD 500 In-stock
5 mg USD 1080 In-stock
10 mg   Get quote  
50 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Umifoxolaner Related Antibodies

Top Publications Citing Use of Products

View All Parasite Isoform Specific Products:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • Biological Activity

  • Purity & Documentation

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Description

Umifoxolaner is an anti-parasitic agent (veterinary).

Molecular Weight

643.86

Formula

C26H16ClF10N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)([C@@]1(C2=CC(C(F)(F)F)=C(C(Cl)=C2)F)CC(C3=CC=C(C(NCC(NCC(F)(F)F)=O)=O)C4=C3C=CC=C4)=NO1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (155.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5531 mL 7.7657 mL 15.5313 mL
5 mM 0.3106 mL 1.5531 mL 3.1063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (3.88 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5531 mL 7.7657 mL 15.5313 mL 38.8283 mL
5 mM 0.3106 mL 1.5531 mL 3.1063 mL 7.7657 mL
10 mM 0.1553 mL 0.7766 mL 1.5531 mL 3.8828 mL
15 mM 0.1035 mL 0.5177 mL 1.0354 mL 2.5886 mL
20 mM 0.0777 mL 0.3883 mL 0.7766 mL 1.9414 mL
25 mM 0.0621 mL 0.3106 mL 0.6213 mL 1.5531 mL
30 mM 0.0518 mL 0.2589 mL 0.5177 mL 1.2943 mL
40 mM 0.0388 mL 0.1941 mL 0.3883 mL 0.9707 mL
50 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7766 mL
60 mM 0.0259 mL 0.1294 mL 0.2589 mL 0.6471 mL
80 mM 0.0194 mL 0.0971 mL 0.1941 mL 0.4854 mL
100 mM 0.0155 mL 0.0777 mL 0.1553 mL 0.3883 mL
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Umifoxolaner Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Umifoxolaner2021230-37-3ML-878ML878ML 878ParasiteInhibitorinhibitorinhibit

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