2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. c-Myc PARP Apoptosis
  4. VPC-70063

VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer.

For research use only. We do not sell to patients.

VPC-70063 Chemical Structure

VPC-70063 Chemical Structure

CAS No. : 13571-44-3

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Based on 1 publication(s) in Google Scholar

VPC-70063 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1].

IC50 & Target

IC50: 8.9 μM (Myc-Max)[1]
Cellular Effect
Cell Line Type Value Description References
LNCaP IC50
2.5 μM
Compound: VPC-70063
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 96 hrs by prestoblue assay
Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 96 hrs by prestoblue assay
[PMID: 30326371]
LNCaP IC50
8.9 μM
Compound: VPC-70063
Inhibition of Myc-Max (unknown origin) expressed in human LNCAP cells assessed as reduction in transcriptional activity after 1 day by luciferase reporter gene assay
Inhibition of Myc-Max (unknown origin) expressed in human LNCAP cells assessed as reduction in transcriptional activity after 1 day by luciferase reporter gene assay
[PMID: 30326371]
In Vitro

VPC-70063 (25 μM; 96 h) shows Myc-Max transcriptional activity inhibition of 106% and Myc-Max/UBE2C downstream pathway inhibition of 94%[1].
VPC-70063 (6.25-25 μM, 48 h) causes apoptosis of LNCaP cells as indicated by cleavage of PARP[1].
VPC-70063 (0-500 μM; 0-600 s) disrupts the interaction of Myc-Max with DNA in a dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VPC-70063 Related Antibodies

Western Blot Analysis[1]

Cell Line: LNCaP cells
Concentration: 6.25 μM, 12.5 μM and 25 μM
Incubation Time: 48 h
Result: Induced PARP cleavage.
Molecular Weight

378.34

Formula

C16H12F6N2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(F)(C1=CC(NC(NCC2=CC=CC=C2)=S)=CC(C(F)(F)F)=C1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (330.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6431 mL 13.2156 mL 26.4313 mL
5 mM 0.5286 mL 2.6431 mL 5.2863 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6431 mL 13.2156 mL 26.4313 mL 66.0781 mL
5 mM 0.5286 mL 2.6431 mL 5.2863 mL 13.2156 mL
10 mM 0.2643 mL 1.3216 mL 2.6431 mL 6.6078 mL
15 mM 0.1762 mL 0.8810 mL 1.7621 mL 4.4052 mL
20 mM 0.1322 mL 0.6608 mL 1.3216 mL 3.3039 mL
25 mM 0.1057 mL 0.5286 mL 1.0573 mL 2.6431 mL
30 mM 0.0881 mL 0.4405 mL 0.8810 mL 2.2026 mL
40 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6520 mL
50 mM 0.0529 mL 0.2643 mL 0.5286 mL 1.3216 mL
60 mM 0.0441 mL 0.2203 mL 0.4405 mL 1.1013 mL
80 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8260 mL
100 mM 0.0264 mL 0.1322 mL 0.2643 mL 0.6608 mL
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VPC-70063 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC-7006313571-44-3VPC70063VPC 70063c-MycPARPApoptosisMycpoly ADP ribose polymerase AnticancerAR-V7UBE2CMyc-MaxLNCaPInhibitorinhibitorinhibit

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