2. Immunology/Inflammation Neuronal Signaling
  3. Interleukin Related Cholinesterase (ChE)
  4. Y13g dihydrochloride

Y13g dihydrochloride is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g dihydrochloride reverses the STZ (HY-13753)-induced memory deficit, and shows histopathology similarly as in normal animals.

For research use only. We do not sell to patients.

Y13g dihydrochloride Chemical Structure

Y13g dihydrochloride Chemical Structure

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5 mg USD 70 In-stock
10 mg USD 120 In-stock
25 mg USD 250 In-stock
50 mg USD 450 In-stock
100 mg USD 750 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Y13g dihydrochloride:

Y13g dihydrochloride Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Y13g dihydrochloride is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g dihydrochloride reverses the STZ (HY-13753)-induced memory deficit, and shows histopathology similarly as in normal animals[1].

IC50 & Target

AChE

 

IL-6

 

Molecular Weight

381.29

Formula

C16H26Cl2N2O4
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=CC(O)=C(C(OC)=C1)C(CCCN2CCNCC2)=O.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (327.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6227 mL 13.1134 mL 26.2268 mL
5 mM 0.5245 mL 2.6227 mL 5.2454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6227 mL 13.1134 mL 26.2268 mL 65.5669 mL
5 mM 0.5245 mL 2.6227 mL 5.2454 mL 13.1134 mL
10 mM 0.2623 mL 1.3113 mL 2.6227 mL 6.5567 mL
15 mM 0.1748 mL 0.8742 mL 1.7485 mL 4.3711 mL
20 mM 0.1311 mL 0.6557 mL 1.3113 mL 3.2783 mL
25 mM 0.1049 mL 0.5245 mL 1.0491 mL 2.6227 mL
30 mM 0.0874 mL 0.4371 mL 0.8742 mL 2.1856 mL
40 mM 0.0656 mL 0.3278 mL 0.6557 mL 1.6392 mL
50 mM 0.0525 mL 0.2623 mL 0.5245 mL 1.3113 mL
60 mM 0.0437 mL 0.2186 mL 0.4371 mL 1.0928 mL
80 mM 0.0328 mL 0.1639 mL 0.3278 mL 0.8196 mL
100 mM 0.0262 mL 0.1311 mL 0.2623 mL 0.6557 mL
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Y13g dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y13gInterleukin RelatedCholinesterase (ChE)ILAChEIL-6Alzheimer's Diseasememory deficithistopathologyInhibitorinhibitorinhibit

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