2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. YC-001

YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration.

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YC-001 Chemical Structure

YC-001 Chemical Structure

CAS No. : 748778-73-6

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

YC-001 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration[1].

IC50 & Target[1]

rod opsin

 

In Vitro

YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150–310%[1].
YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant[1].
YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC50 OF 0.98 µM[1].
YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YC-001 Related Antibodies

Western Blot Analysis[1]

Cell Line: NIH3T3 cells
Concentration: 0.5, 1, 5, 10, 20, 40 µM
Incubation Time:
Result: Improved the glycosylation profile of P23H opsin.
In Vivo

YC-001 (50, 200mg/kg; i.p.) protects Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration[1].
YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods[1].
YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old Abca4 −/−Rdh8−/− mice[1]
Dosage: 50, 200mg/kg
Administration: I.P.
Result: Protected Abca4−/−Rdh8−/− mice from bright light-induced retinal degeneration.
Animal Model: C57BL/6 mouse[1]
Dosage: 200 mg/kg
Administration: I.P.
Result: Entered mouse eyes after systemic administration but is not retained for prolonged periods.
Animal Model: C57BL/6 mice[1]
Dosage: 100 mg/kg, 200 mg/kg
Administration: I.p.; daily, 24 days
Result: Showed no acute toxicity.
Molecular Weight

282.77

Formula

C12H7ClO2S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1OCC(C2=CC=C(Cl)S2)=C1C3=CC=CS3
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (353.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5364 mL 17.6822 mL 35.3644 mL
5 mM 0.7073 mL 3.5364 mL 7.0729 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (8.84 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5364 mL 17.6822 mL 35.3644 mL 88.4111 mL
5 mM 0.7073 mL 3.5364 mL 7.0729 mL 17.6822 mL
10 mM 0.3536 mL 1.7682 mL 3.5364 mL 8.8411 mL
15 mM 0.2358 mL 1.1788 mL 2.3576 mL 5.8941 mL
20 mM 0.1768 mL 0.8841 mL 1.7682 mL 4.4206 mL
25 mM 0.1415 mL 0.7073 mL 1.4146 mL 3.5364 mL
30 mM 0.1179 mL 0.5894 mL 1.1788 mL 2.9470 mL
40 mM 0.0884 mL 0.4421 mL 0.8841 mL 2.2103 mL
50 mM 0.0707 mL 0.3536 mL 0.7073 mL 1.7682 mL
60 mM 0.0589 mL 0.2947 mL 0.5894 mL 1.4735 mL
80 mM 0.0442 mL 0.2210 mL 0.4421 mL 1.1051 mL
100 mM 0.0354 mL 0.1768 mL 0.3536 mL 0.8841 mL
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YC-001 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YC-001748778-73-6YC001YC 001Endogenous MetaboliteChaperone9-cis-retinal retinal degenerationacute toxicitylightcAMPNIH3T3 cellsInhibitorinhibitorinhibit

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