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YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation.

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YMU1 Chemical Structure

YMU1 Chemical Structure

CAS No. : 902589-96-2

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Based on 1 publication(s) in Google Scholar

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Description

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation[1][2].

IC50 & Target

STAT3

 

In Vitro

YMU1 (0.1-10 μM, 10 min) has no inhibitory effect on TK1[1].
YMU1 is not toxic to the genome and, similar to TMPK silencing, impaires DSB repair[1].
YMU1 (1-10 μM, 14 days) has little effect on cell growth in H184B5F5M10, MCF10A, MCF-7, and HCT-116 cells[1].
YMU1 does not inhibit dUTPase in vitro[1].
YMU1 sensitizes malignant tumor cells to doxorubicin in vitro[1].
YMU1 (3-10 μM, 72 h) inhibits A549 cell proliferation, migration, and invasion[2].
YMU1 (3-10 μM, 72 h) controls the activation of STAT3 signaling pathway in LUAD cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YMU1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: H184B5F5M10, MCF10A, MCF-7, HCT-116
Concentration: 1, 10 μM
Incubation Time: 14 days; twice a week
Result: Had little effect on cell growth.

Cell Viability Assay[2]

Cell Line: A549
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Decreased cell viability.

Cell Migration Assay [2]

Cell Line: A549
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Inhibited cell migration.

Cell Invasion Assay[2]

Cell Line: A549
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Inhibited cell invasion.

Western Blot Analysis[2]

Cell Line: A549; LUAD
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Increased E-Cadherin approximately 3-fold, reduced N-Cadherin, fibronectin, and vimentin by more than 50%, and significantly reduced pSTAT3 levels, while total STAT3 levels had no significant change.
In Vivo

YMU1 (5 mg/kg, intraperitoneal injection, three times a week, for 25 days) and doxorubicin co-administered to mice inhibits tumor growth[1].
YMU1 (3-10 mg/kg, intraperitoneal injection, once every two days, for 30 days) inhibits the growth of A549 xenograft tumors in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT-116 p53-/- cell transplantation model in nude mice[1]
Dosage: 5 mg/kg; 3 times a week; 25 days
Administration: Intraperitoneal injection (i.p.)
Result: Showed that tumors grew significantly slower in mice treated with doxorubicin.
Animal Model: A549 nude mouse transplantation model[2]
Dosage: 3,10 mg/kg; once every two days; 30 days
Administration: Intraperitoneal injection (i.p.)
Result: Reduced tumor volume and weight in a dose-dependent manner.
Molecular Weight

378.45

Formula

C17H22N4O4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.56 mg/mL (14.69 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6424 mL 13.2118 mL 26.4236 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6424 mL 13.2118 mL 26.4236 mL 66.0589 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL 13.2118 mL
10 mM 0.2642 mL 1.3212 mL 2.6424 mL 6.6059 mL
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YMU1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YMU1902589-96-2YMU 1YMU-1OthersSTATAnti-tumorA549HCT116doxorubicinInhibitorinhibitorinhibit

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