1. Others Stem Cell/Wnt JAK/STAT Signaling
  2. Others STAT
  3. YMU1

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation.

For research use only. We do not sell to patients.

YMU1 Chemical Structure

YMU1 Chemical Structure

CAS No. : 902589-96-2

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 90 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 720 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All STAT Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation[1][2].

IC50 & Target

STAT3

 

In Vitro

YMU1 (0.1-10 μM, 10 min) has no inhibitory effect on TK1[1].
YMU1 is not toxic to the genome and, similar to TMPK silencing, impaires DSB repair[1].
YMU1 (1-10 μM, 14 days) has little effect on cell growth in H184B5F5M10, MCF10A, MCF-7, and HCT-116 cells[1].
YMU1 does not inhibit dUTPase in vitro[1].
YMU1 sensitizes malignant tumor cells to doxorubicin in vitro[1].
YMU1 (3-10 μM, 72 h) inhibits A549 cell proliferation, migration, and invasion[2].
YMU1 (3-10 μM, 72 h) controls the activation of STAT3 signaling pathway in LUAD cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H184B5F5M10, MCF10A, MCF-7, HCT-116
Concentration: 1, 10 μM
Incubation Time: 14 days; twice a week
Result: Had little effect on cell growth.

Cell Viability Assay[2]

Cell Line: A549
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Decreased cell viability.

Cell Migration Assay [2]

Cell Line: A549
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Inhibited cell migration.

Cell Invasion Assay[2]

Cell Line: A549
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Inhibited cell invasion.

Western Blot Analysis[2]

Cell Line: A549; LUAD
Concentration: 3, 10 μM
Incubation Time: 72 h
Result: Increased E-Cadherin approximately 3-fold, reduced N-Cadherin, fibronectin, and vimentin by more than 50%, and significantly reduced pSTAT3 levels, while total STAT3 levels had no significant change.
In Vivo

YMU1 (5 mg/kg, intraperitoneal injection, three times a week, for 25 days) and doxorubicin co-administered to mice inhibits tumor growth[1].
YMU1 (3-10 mg/kg, intraperitoneal injection, once every two days, for 30 days) inhibits the growth of A549 xenograft tumors in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT-116 p53-/- cell transplantation model in nude mice[1]
Dosage: 5 mg/kg; 3 times a week; 25 days
Administration: Intraperitoneal injection (i.p.)
Result: Showed that tumors grew significantly slower in mice treated with doxorubicin.
Animal Model: A549 nude mouse transplantation model[2]
Dosage: 3,10 mg/kg; once every two days; 30 days
Administration: Intraperitoneal injection (i.p.)
Result: Reduced tumor volume and weight in a dose-dependent manner.
Molecular Weight

378.45

Formula

C17H22N4O4S

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5.56 mg/mL (14.69 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6424 mL 13.2118 mL 26.4236 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.00%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6424 mL 13.2118 mL 26.4236 mL 66.0589 mL
5 mM 0.5285 mL 2.6424 mL 5.2847 mL 13.2118 mL
10 mM 0.2642 mL 1.3212 mL 2.6424 mL 6.6059 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
YMU1
Cat. No.:
HY-129125
Quantity:
MCE Japan Authorized Agent: