2. PROTAC
  3. Molecular Glues Ligands for E3 Ligase
  4. ZXH-1-161

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma.

For research use only. We do not sell to patients.

ZXH-1-161 Chemical Structure

ZXH-1-161 Chemical Structure

CAS No. : 2407654-51-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

ZXH-1-161 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1].

IC50 & Target

IC50: 39 μM in MM1.S wild type cells[1]
Molecular Weight

468.51

Formula

C26H24N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C(CC1)N2C(C3=C(C2)C(NC4=NC(NC5=CC=C6C(CCC6)=C5)=NC=C4)=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (533.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1344 mL 10.6721 mL 21.3443 mL
5 mM 0.4269 mL 2.1344 mL 4.2689 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1344 mL 10.6721 mL 21.3443 mL 53.3607 mL
5 mM 0.4269 mL 2.1344 mL 4.2689 mL 10.6721 mL
10 mM 0.2134 mL 1.0672 mL 2.1344 mL 5.3361 mL
15 mM 0.1423 mL 0.7115 mL 1.4230 mL 3.5574 mL
20 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6680 mL
25 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1344 mL
30 mM 0.0711 mL 0.3557 mL 0.7115 mL 1.7787 mL
40 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
50 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
60 mM 0.0356 mL 0.1779 mL 0.3557 mL 0.8893 mL
80 mM 0.0267 mL 0.1334 mL 0.2668 mL 0.6670 mL
100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.5336 mL
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ZXH-1-161 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZXH-1-1612407654-51-5Molecular GluesLigands for E3 LigaseE3 ligase-recruiting MoietyMM1.Smultiple myelomaGSPT1Inhibitorinhibitorinhibit

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