19-Hydroxyandrost-4-ene-3,17-dione

Name: 19-Hydroxyandrost-4-ene-3,17-dione
Brand: MedChemExpress
SKU: HY-113302
Rating: 4.5 (1 reviews)

Cat. No.: HY-113302 Purity: 99.11%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

19-Hydroxyandrost-4-ene-3,17-dione is a substrate for Corticotropin-lipotropin and Cytochrome P450 19A1.

For research use only. We do not sell to patients.

19-Hydroxyandrost-4-ene-3,17-dione Chemical Structure

CAS No. : 510-64-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 26	In-stock	Estimated Time of Arrival: April 21
Solution
10 mM * 1 mL in DMSO	USD 27	In-stock	Estimated Time of Arrival: April 21
Solid
100 mg	USD 25	In-stock	Estimated Time of Arrival: April 21
500 mg	USD 50	In-stock	Estimated Time of Arrival: April 21
1 g		Get quote
5 g		Get quote

Get it by April 21 for select sizes. Order within 21 hrs 17 mins.

or Bulk Inquiry

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

Biological Activity
Purity & Documentation
References
Customer Review

Description

19-Hydroxyandrost-4-ene-3,17-dione is a substrate for Corticotropin-lipotropin and Cytochrome P450 19A1.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

302.41

Formula

C₁₉H₂₆O₃

CAS No.

510-64-5

Appearance

Solid

Color

White to off-white

SMILES

C[C@]1([C@](CC2)([H])[C@]3([H])CCC4=CC(CC[C@]4(CO)[C@@]3([H])CC1)=O)C2=O

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (330.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3068 mL	16.5338 mL	33.0677 mL
5 mM	0.6614 mL	3.3068 mL	6.6135 mL
10 mM	0.3307 mL	1.6534 mL	3.3068 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (255 KB) HNMR (248 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Wilcox RB, et al. Kinetic studies on the role of 19-hydroxyandrost-4-ene-3,17-dione in estrogen biosynthesis. Steroids. 1965;58:SUPPL 1:49-57. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3068 mL	16.5338 mL	33.0677 mL	82.6692 mL
	5 mM	0.6614 mL	3.3068 mL	6.6135 mL	16.5338 mL
	10 mM	0.3307 mL	1.6534 mL	3.3068 mL	8.2669 mL
	15 mM	0.2205 mL	1.1023 mL	2.2045 mL	5.5113 mL
	20 mM	0.1653 mL	0.8267 mL	1.6534 mL	4.1335 mL
	25 mM	0.1323 mL	0.6614 mL	1.3227 mL	3.3068 mL
	30 mM	0.1102 mL	0.5511 mL	1.1023 mL	2.7556 mL
	40 mM	0.0827 mL	0.4133 mL	0.8267 mL	2.0667 mL
	50 mM	0.0661 mL	0.3307 mL	0.6614 mL	1.6534 mL
	60 mM	0.0551 mL	0.2756 mL	0.5511 mL	1.3778 mL
	80 mM	0.0413 mL	0.2067 mL	0.4133 mL	1.0334 mL
	100 mM	0.0331 mL	0.1653 mL	0.3307 mL	0.8267 mL