2-Aminobenzenesulfonamide (Synonyms: Orthanilamide)

Cat. No.: HY-B2147 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor.

For research use only. We do not sell to patients.

2-Aminobenzenesulfonamide Chemical Structure

CAS No. : 3306-62-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 79	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 79	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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CA CA I CA Ⅱ CA Ⅸ CA XII

Biological Activity
Purity & Documentation
References
Customer Review

Description

2-Aminobenzenesulfonamide is a carbonic anhydrase IX inhibitor.

IC₅₀ & Target

CA Ⅸ

Molecular Weight

172.20

Formula

C₆H₈N₂O₂S

CAS No.

3306-62-5

Appearance

Solid

Color

White to light brown

SMILES

O=S(C1=CC=CC=C1N)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (1161.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8072 mL	29.0360 mL	58.0720 mL
5 mM	1.1614 mL	5.8072 mL	11.6144 mL
10 mM	0.5807 mL	2.9036 mL	5.8072 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (29.04 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (29.04 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (254 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Vullo D, et al. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1005-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8072 mL	29.0360 mL	58.0720 mL	145.1800 mL
	5 mM	1.1614 mL	5.8072 mL	11.6144 mL	29.0360 mL
	10 mM	0.5807 mL	2.9036 mL	5.8072 mL	14.5180 mL
	15 mM	0.3871 mL	1.9357 mL	3.8715 mL	9.6787 mL
	20 mM	0.2904 mL	1.4518 mL	2.9036 mL	7.2590 mL
	25 mM	0.2323 mL	1.1614 mL	2.3229 mL	5.8072 mL
	30 mM	0.1936 mL	0.9679 mL	1.9357 mL	4.8393 mL
	40 mM	0.1452 mL	0.7259 mL	1.4518 mL	3.6295 mL
	50 mM	0.1161 mL	0.5807 mL	1.1614 mL	2.9036 mL
	60 mM	0.0968 mL	0.4839 mL	0.9679 mL	2.4197 mL
	80 mM	0.0726 mL	0.3630 mL	0.7259 mL	1.8148 mL
	100 mM	0.0581 mL	0.2904 mL	0.5807 mL	1.4518 mL

2-Aminobenzenesulfonamide Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Aminobenzenesulfonamide3306-62-5OrthanilamideCarbonic AnhydraseCarbonate dehydrataseInhibitorinhibitorinhibit

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