2'-Deoxyadenosine monohydrate

Name: 2'-Deoxyadenosine monohydrate
Brand: MedChemExpress
SKU: HY-W011683
Rating: 4.5 (1 reviews)

Cat. No.: HY-W011683 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2'-Deoxyadenosine monohydrate is a deoxyribonucleoside. A building block in the chemical synthesis.

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2'-Deoxyadenosine monohydrate Chemical Structure

CAS No. : 16373-93-6

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Based on 1 publication(s) in Google Scholar

Other Forms of 2'-Deoxyadenosine monohydrate:

2'-Deoxyadenosine In-stock
2'-Deoxyadenosine monohydrate-1′-¹³C Get quote
2'-Deoxyadenosine monohydrate-2′-¹³C Get quote
2'-Deoxyadenosine monohydrate-3′-¹³C Get quote
2'-Deoxyadenosine monohydrate-5′-¹³C Get quote
2'-Deoxyadenosine monohydrate-¹³C₁₀,¹⁵N₅ hydrate Get quote
2'-Deoxyadenosine monohydrate-¹⁵N₅ Get quote

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Description

2'-Deoxyadenosine monohydrate is a deoxyribonucleoside. A building block in the chemical synthesis.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Molecular Weight

269.26

Formula

C₁₀H₁₅N₅O₄

CAS No.

16373-93-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CO.O

Structure Classification

Others

Initial Source

Microorganisms

Streptomyces jiujiangensis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (185.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 7.14 mg/mL (26.52 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7139 mL	18.5694 mL	37.1388 mL
5 mM	0.7428 mL	3.7139 mL	7.4278 mL
10 mM	0.3714 mL	1.8569 mL	3.7139 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (251 KB) SDS (479 KB)

COA (255 KB) RP-HPLC (205 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.7139 mL	18.5694 mL	37.1388 mL	92.8471 mL
	5 mM	0.7428 mL	3.7139 mL	7.4278 mL	18.5694 mL
	10 mM	0.3714 mL	1.8569 mL	3.7139 mL	9.2847 mL
	15 mM	0.2476 mL	1.2380 mL	2.4759 mL	6.1898 mL
	20 mM	0.1857 mL	0.9285 mL	1.8569 mL	4.6424 mL
	25 mM	0.1486 mL	0.7428 mL	1.4856 mL	3.7139 mL
DMSO	30 mM	0.1238 mL	0.6190 mL	1.2380 mL	3.0949 mL
	40 mM	0.0928 mL	0.4642 mL	0.9285 mL	2.3212 mL
	50 mM	0.0743 mL	0.3714 mL	0.7428 mL	1.8569 mL
	60 mM	0.0619 mL	0.3095 mL	0.6190 mL	1.5475 mL
	80 mM	0.0464 mL	0.2321 mL	0.4642 mL	1.1606 mL
	100 mM	0.0371 mL	0.1857 mL	0.3714 mL	0.9285 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.