2. Cell Cycle/DNA Damage Anti-infection Apoptosis Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog HIV Apoptosis Endogenous Metabolite
  4. 5-Fluorouracil-d

5-Fluorouracil-d  (Synonyms: 5-FU-d1)

Cat. No.: HY-90006S Purity: 99.42%
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5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

For research use only. We do not sell to patients.

5-Fluorouracil-d Chemical Structure

5-Fluorouracil-d Chemical Structure

CAS No. : 90344-84-6

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1 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Fluorouracil-d:

5-Fluorouracil-d Related Antibodies

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Description

5-Fluorouracil-d is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil induces apoptosis and can be used as a chemical sensitizer[1][2]. 5-Fluorouracil also inhibits HIV[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-Fluorouracil-d Related Antibodies
Molecular Weight

131.08

Formula

C4H2DFN2O2
CAS No.
Unlabeled CAS

51-21-8
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(F)=C([2H])NC(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (381.45 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6289 mL 38.1446 mL 76.2893 mL
5 mM 1.5258 mL 7.6289 mL 15.2579 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.6289 mL 38.1446 mL 76.2893 mL 190.7232 mL
5 mM 1.5258 mL 7.6289 mL 15.2579 mL 38.1446 mL
10 mM 0.7629 mL 3.8145 mL 7.6289 mL 19.0723 mL
15 mM 0.5086 mL 2.5430 mL 5.0860 mL 12.7149 mL
20 mM 0.3814 mL 1.9072 mL 3.8145 mL 9.5362 mL
25 mM 0.3052 mL 1.5258 mL 3.0516 mL 7.6289 mL
30 mM 0.2543 mL 1.2715 mL 2.5430 mL 6.3574 mL
40 mM 0.1907 mL 0.9536 mL 1.9072 mL 4.7681 mL
50 mM 0.1526 mL 0.7629 mL 1.5258 mL 3.8145 mL
60 mM 0.1271 mL 0.6357 mL 1.2715 mL 3.1787 mL
80 mM 0.0954 mL 0.4768 mL 0.9536 mL 2.3840 mL
100 mM 0.0763 mL 0.3814 mL 0.7629 mL 1.9072 mL
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5-Fluorouracil-d Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Fluorouracil-d90344-84-65-FU-d1Nucleoside Antimetabolite/AnalogHIVApoptosisEndogenous MetaboliteHuman immunodeficiency virusInhibitorinhibitorinhibit

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