7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA

Cat. No.: HY-132160A Purity: 96.52%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (HY-132158). 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA can be used for the synthesis of camptothecin antibody-drug conjugate (ADC).

For research use only. We do not sell to patients.

7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 7-Aminomethyl-10-methyl-11-fluoro camptothecin TFA:

7-Aminomethyl-10-methyl-11-fluoro camptothecin Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

523.43

Formula

C₂₄H₂₁F₄N₃O₆

Appearance

Solid

Color

Light yellow to yellow

SMILES

NCC1=C2C(C(N3C2)=CC([C@]4(CC)O)=C(C3=O)COC4=O)=NC5=CC(F)=C(C=C51)C.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (47.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9105 mL	9.5524 mL	19.1048 mL
5 mM	0.3821 mL	1.9105 mL	3.8210 mL
10 mM	0.1910 mL	0.9552 mL	1.9105 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.52%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (250 KB) HNMR (420 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10(10):1386-1392. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9105 mL	9.5524 mL	19.1048 mL	47.7619 mL
	5 mM	0.3821 mL	1.9105 mL	3.8210 mL	9.5524 mL
	10 mM	0.1910 mL	0.9552 mL	1.9105 mL	4.7762 mL
	15 mM	0.1274 mL	0.6368 mL	1.2737 mL	3.1841 mL
	20 mM	0.0955 mL	0.4776 mL	0.9552 mL	2.3881 mL
	25 mM	0.0764 mL	0.3821 mL	0.7642 mL	1.9105 mL
	30 mM	0.0637 mL	0.3184 mL	0.6368 mL	1.5921 mL
	40 mM	0.0478 mL	0.2388 mL	0.4776 mL	1.1940 mL