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Atractylodin  (Synonyms: Atractydin)

Cat. No.: HY-N0238 Purity: 99.99%
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Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity.

For research use only. We do not sell to patients.

Atractylodin Chemical Structure

Atractylodin Chemical Structure

CAS No. : 55290-63-6

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10 mg USD 170 In-stock
25 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Atractylodin:

Atractylodin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Atractylodin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity[1][2][3].

In Vitro

Atractylodin (50 μM, 48 h) significantly inhibits tumor necrosis factor-α-induced activated B-nuclear factor-κ-light chain enhancer phosphorylation in HCT116 cells[2].
Atractylodin (10, 20, 40 μM, 24 h) alleviates HFD-induced NAFLD by inhibiting hepatocyte sideroptosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Atractylodin Related Antibodies

Cell Viability Assay[2]

Cell Line: NCM460, SW480, HCT116
Concentration: 1, 10, 25, 50, 100 μM
Incubation Time: 24 h
Result: Decreased viability at a concentration of 100 µM in HCT116 cells.

Western Blot Analysis[2]

Cell Line: HCT116
Concentration: 50 μM
Incubation Time: 1 h
Result: Inhibited TNF-α-induced phosphorylation of NF-κB p65.
In Vivo

Atractylodin (40 mg/kg intraperitoneally injected for 14 days) can improve the survival rate of mice in a mouse model of colitis induced by sodium dextran sulfate[2].
Atractylodin (20, 40, 80 mg/kg, gavage) alleviates the oxidative stress of HepG2 cells induced by high-fat diet (HFD) and palmitic acid (PA) in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS-Induced Colitis Mouse Model[2]
Dosage: 40 mg/kg
Administration: i.p.
Result: Reduced colitis symptoms and increased survival rate.
Animal Model: NAFLD mice model[3]
Dosage: 20, 40, 80 mg/kg
Administration: i.g.
Result: Reduced the release of ALT, AST, ROS and MDA.
Increased the TG, GSH and SOD.
Molecular Weight

182.22

Formula

C13H10O
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

C/C=C/C#CC#C/C=C/C1=CC=CO1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 6 mg/mL (32.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4879 mL 27.4394 mL 54.8787 mL
5 mM 1.0976 mL 5.4879 mL 10.9757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

SDS (393 KB)

COA (240 KB) RP-HPLC (206 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4879 mL 27.4394 mL 54.8787 mL 137.1968 mL
5 mM 1.0976 mL 5.4879 mL 10.9757 mL 27.4394 mL
10 mM 0.5488 mL 2.7439 mL 5.4879 mL 13.7197 mL
15 mM 0.3659 mL 1.8293 mL 3.6586 mL 9.1465 mL
20 mM 0.2744 mL 1.3720 mL 2.7439 mL 6.8598 mL
25 mM 0.2195 mL 1.0976 mL 2.1951 mL 5.4879 mL
30 mM 0.1829 mL 0.9146 mL 1.8293 mL 4.5732 mL
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Atractylodin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atractylodin55290-63-6AtractydinOthersAnti-inflammatoryInsecticideHCT116HFDDSSInhibitorinhibitorinhibit

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