Benzydamine hydrochloride

Name: Benzydamine hydrochloride
Brand: MedChemExpress
SKU: HY-30235A
Rating: 4.5 (1 reviews)

Cat. No.: HY-30235A Purity: 98.22%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Benzydamine hydrochloride is an orally administered prostaglandin synthesis inhibitor that has anti-inflammatory, analgesic, antipyretic, and antibacterial properties. Benzydamine hydrochloride can inhibit TNF-α, stabilize cell membranes, and reduce oxidative stress within cells.

For research use only. We do not sell to patients.

Benzydamine hydrochloride Chemical Structure

CAS No. : 132-69-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Benzydamine hydrochloride:

Benzydamine-d₆ hydrochloride Get quote
Benzydamine Get quote
Benzydamine hydrochloride (Standard) Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All TNF Receptor Isoform Specific Products:

View All Isoforms

TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Benzydamine hydrochloride has a MIC of 0.5 mg/mL and a MLC of 1.0 mg/mL against Escherichia coli, ATCC 8739, and a MIC of 1.0 mg/mL and a MLC of 1.0 mg/mL against Proteus vulgaris, ATCC 13315^[1].
Benzydamine (1.0 mg/mL, 24 h) hydrochloride inhibits the proliferation of Ps. Aeruginosa^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Ps. aeruginosa
Concentration:	1.0 mg/mL
Incubation Time:	24 h
Result:	Inhibited the proliferation of Ps. aeruginosa.

Clinical Trial

Molecular Weight

345.87

Formula

C₁₉H₂₄ClN₃O

CAS No.

132-69-4

Appearance

Solid

Color

White to off-white

SMILES

CN(C)CCCOC1=NN(CC2=CC=CC=C2)C3=C1C=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 41 mg/mL (118.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8913 mL	14.4563 mL	28.9126 mL
5 mM	0.5783 mL	2.8913 mL	5.7825 mL
10 mM	0.2891 mL	1.4456 mL	2.8913 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (289.13 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.22%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (251 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Fanaki NH, et al. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992 Dec;4(6):347-52. [Content Brief]

[2]. Quane PA, Pharmacology of benzydamine. Inflammopharmacology. 1998;6(2):95-107 [Content Brief]

[3]. R S Turnbull, et al. Benzydamine Hydrochloride (Tantum) in the management of oral inflammatory conditions. J Can Dent Assoc. 1995 Feb;61(2):127-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.8913 mL	14.4563 mL	28.9126 mL	72.2815 mL
	5 mM	0.5783 mL	2.8913 mL	5.7825 mL	14.4563 mL
	10 mM	0.2891 mL	1.4456 mL	2.8913 mL	7.2281 mL
	15 mM	0.1928 mL	0.9638 mL	1.9275 mL	4.8188 mL
	20 mM	0.1446 mL	0.7228 mL	1.4456 mL	3.6141 mL
	25 mM	0.1157 mL	0.5783 mL	1.1565 mL	2.8913 mL
	30 mM	0.0964 mL	0.4819 mL	0.9638 mL	2.4094 mL
	40 mM	0.0723 mL	0.3614 mL	0.7228 mL	1.8070 mL
	50 mM	0.0578 mL	0.2891 mL	0.5783 mL	1.4456 mL
	60 mM	0.0482 mL	0.2409 mL	0.4819 mL	1.2047 mL
	80 mM	0.0361 mL	0.1807 mL	0.3614 mL	0.9035 mL
	100 mM	0.0289 mL	0.1446 mL	0.2891 mL	0.7228 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.