2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. D-Pantothenic acid sodium

D-Pantothenic acid sodium  (Synonyms: Sodium pantothenate; Vitamin B5 sodium)

Cat. No.: HY-B0430A Purity: ≥98.0%
COA Handling Instructions

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D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.

For research use only. We do not sell to patients.

D-Pantothenic acid sodium Chemical Structure

D-Pantothenic acid sodium Chemical Structure

CAS No. : 867-81-2

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10 mM * 1 mL in DMSO
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Based on 3 publication(s) in Google Scholar

Other Forms of D-Pantothenic acid sodium:

D-Pantothenic acid sodium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

D-Pantothenic acid sodium (Sodium pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid sodium plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

D-Pantothenic acid sodium is a precursor to coenzyme A and is primarily involved in energy production and lipid metabolism through the TCA cycle and the β-oxidation pathway, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Pantothenic acid sodium Related Antibodies
In Vivo

Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice weighing 29-35 g[2]
Dosage: 3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered)
Administration: Injected intraperitoneally (i.p.) on day 8.5 of gestation
Result: Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced.
Molecular Weight

241.22

Formula

C9H16NNaO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(C)(C)[C@@H](O)C(NCCC(O[Na])=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (414.56 mM; Need ultrasonic)

DMSO : 5 mg/mL (20.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1456 mL 20.7280 mL 41.4559 mL
5 mM 0.8291 mL 4.1456 mL 8.2912 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (2.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.5 mg/mL (2.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 120 mg/mL (497.47 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (244 KB) HNMR (242 KB) MS (179 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.1456 mL 20.7280 mL 41.4559 mL 103.6398 mL
5 mM 0.8291 mL 4.1456 mL 8.2912 mL 20.7280 mL
10 mM 0.4146 mL 2.0728 mL 4.1456 mL 10.3640 mL
15 mM 0.2764 mL 1.3819 mL 2.7637 mL 6.9093 mL
20 mM 0.2073 mL 1.0364 mL 2.0728 mL 5.1820 mL
H2O 25 mM 0.1658 mL 0.8291 mL 1.6582 mL 4.1456 mL
30 mM 0.1382 mL 0.6909 mL 1.3819 mL 3.4547 mL
40 mM 0.1036 mL 0.5182 mL 1.0364 mL 2.5910 mL
50 mM 0.0829 mL 0.4146 mL 0.8291 mL 2.0728 mL
60 mM 0.0691 mL 0.3455 mL 0.6909 mL 1.7273 mL
80 mM 0.0518 mL 0.2591 mL 0.5182 mL 1.2955 mL
100 mM 0.0415 mL 0.2073 mL 0.4146 mL 1.0364 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Pantothenic acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Pantothenic acid867-81-2Sodium pantothenateVitamin B5Vitamin B 5Vitamin B-5ApoptosisEndogenous MetaboliteInhibitorinhibitorinhibit

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