2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. D-Pantothenic acid hemicalcium salt

D-Pantothenic acid hemicalcium salt  (Synonyms: Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt)

Cat. No.: HY-N0681 Purity: ≥98.0%
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COA
Handling Instructions Technical Support

D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity。

For research use only. We do not sell to patients.

D-Pantothenic acid hemicalcium salt Chemical Structure

D-Pantothenic acid hemicalcium salt Chemical Structure

CAS No. : 137-08-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
500 mg In-stock
5 g In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of D-Pantothenic acid hemicalcium salt:

D-Pantothenic acid hemicalcium salt Related Antibodies

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Description

D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity[1][2][3][4][5][6][7][8]。
IC50 & Target

Human Endogenous Metabolite

 

In Vitro

D-Pantothenic acid (Vitamin B5, 1-2.5 mM) hemicalcium salt restrains Th17 cell differentiation through CoA in a PANK-dependent manner[3].
D-Pantothenic acid (50-1000 µM, 3 days) hemicalcium salt inhibits RANKL induced osteoclastogenesis by scavenging ROS generation in BMMs cells[5].
D-Pantothenic acid (2  mM, 4 days) hemicalcium salt rescues a membrane trafficking defect in human fibroblasts devoid of TANGO2[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Pantothenic acid hemicalcium salt Related Antibodies
In Vivo

D-Pantothenic acid hemicalcium salt (10 mg/kg, oral gavage, daily) protects against obesity via brown adipose tissue activation in C57BL/6J mice[4].
D-Pantothenic acid (Vitamin B5, 50mg/kg/day, drinking water, 2 weeks) hemicalcium salt alleviates experimental autoimmune encephalomyelitis in C57BL/6 mice[3].
D-Pantothenic acid (pantothenic acid rich dietary, feed, four weeks) hemicalcium salt alleviates bone loss in an osteoporotic model of OVX mice[5].
D-Pantothenic acid (0.1 mg/kg, p.o., starts from the day after infection and performs every day until the end of 4 weeks) hemicalcium salt reduces bacterial growth via regulating innate immunity and adaptive immunity in mice infected with mycobacterium tuberculosis[6].
D-Pantothenic acid (50  ppm, diet, 28 days) hemicalcium salt enhances intestinal development and alters microbes in weaned piglets, with enhancing the morphological structure, cell proliferation and differentiation of the ileum, cecum and colon[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

238.27

Formula

C9H16NO5.1/2Ca
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C(NCCC([O-])=O)=O)C(C)(C)CO.[0.5Ca2+]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (419.69 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (419.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1969 mL 20.9846 mL 41.9692 mL
5 mM 0.8394 mL 4.1969 mL 8.3938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (419.69 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (249 KB) HNMR (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.1969 mL 20.9846 mL 41.9692 mL 104.9230 mL
5 mM 0.8394 mL 4.1969 mL 8.3938 mL 20.9846 mL
10 mM 0.4197 mL 2.0985 mL 4.1969 mL 10.4923 mL
15 mM 0.2798 mL 1.3990 mL 2.7979 mL 6.9949 mL
20 mM 0.2098 mL 1.0492 mL 2.0985 mL 5.2461 mL
25 mM 0.1679 mL 0.8394 mL 1.6788 mL 4.1969 mL
30 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4974 mL
40 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6231 mL
50 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0985 mL
60 mM 0.0699 mL 0.3497 mL 0.6995 mL 1.7487 mL
80 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3115 mL
100 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0492 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Pantothenic acid hemicalcium salt Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Pantothenic acid hemicalcium137-08-6Calcium pantothenate Calcium D-pantothenateVitamin B5Vitamin B 5Vitamin B-5Reactive Oxygen SpeciesOsteoporosisObesityAntibacterial and Immunomodulatory.Inhibitorinhibitorinhibit

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