DL-Homocysteine thiolactone hydrochloride

Name: DL-Homocysteine thiolactone hydrochloride
Brand: MedChemExpress
SKU: HY-101404
Rating: 4.5 (1 reviews)

Cat. No.: HY-101404 Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

For research use only. We do not sell to patients.

DL-Homocysteine thiolactone hydrochloride Chemical Structure

CAS No. : 6038-19-3

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Free Sample (0.1 - 0.5 mg)		Apply Now
5 g	USD 30	In-stock	Estimated Time of Arrival: December 31
10 g	USD 45	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of DL-Homocysteine thiolactone hydrochloride:

L-Homocysteine thiolactone hydrochloride In-stock
DL-Homocysteine thiolactone-d₄ hydrochloride Get quote
DL-Homocysteine thiolactone hydrochloride (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

In Vitro

DL-Homocysteine thiolactone hydrochloride shows growth inhibition toward the roots of Brassica campestris and Echinochloa utilis even at the low concentration of 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

153.63

Formula

C₄H₈ClNOS

CAS No.

6038-19-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1C(N)CCS1.Cl

Structure Classification

Amino acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (325.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5091 mL	32.5457 mL	65.0915 mL
5 mM	1.3018 mL	6.5091 mL	13.0183 mL
10 mM	0.6509 mL	3.2546 mL	6.5091 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) HNMR (248 KB) RP-HPLC (197 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Yoshihiko INAMORI, et al. Root-growth Inhibition by DL-Homocysteine Thiolactone and Its Related Compounds. Biosci. Biotech. Biochem., 59 (3), 523-525, 1995.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5091 mL	32.5457 mL	65.0915 mL	162.7286 mL
	5 mM	1.3018 mL	6.5091 mL	13.0183 mL	32.5457 mL
	10 mM	0.6509 mL	3.2546 mL	6.5091 mL	16.2729 mL
	15 mM	0.4339 mL	2.1697 mL	4.3394 mL	10.8486 mL
	20 mM	0.3255 mL	1.6273 mL	3.2546 mL	8.1364 mL
	25 mM	0.2604 mL	1.3018 mL	2.6037 mL	6.5091 mL
	30 mM	0.2170 mL	1.0849 mL	2.1697 mL	5.4243 mL
	40 mM	0.1627 mL	0.8136 mL	1.6273 mL	4.0682 mL
	50 mM	0.1302 mL	0.6509 mL	1.3018 mL	3.2546 mL
	60 mM	0.1085 mL	0.5424 mL	1.0849 mL	2.7121 mL
	80 mM	0.0814 mL	0.4068 mL	0.8136 mL	2.0341 mL
	100 mM	0.0651 mL	0.3255 mL	0.6509 mL	1.6273 mL