Gabexate mesylate (Synonyms: FOY)

Name: Gabexate mesylate
Brand: MedChemExpress
SKU: HY-B0385
Rating: 5.0 (4 reviews)

Cat. No.: HY-B0385 Purity: 99.14%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation.

For research use only. We do not sell to patients.

Gabexate mesylate Chemical Structure

CAS No. : 56974-61-9

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 112	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 112	In-stock	Estimated Time of Arrival: December 31
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5 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 102	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 396	In-stock	Estimated Time of Arrival: December 31
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Based on 4 publication(s) in Google Scholar

Other Forms of Gabexate mesylate:

Gabexate mesylate (Standard) Get quote

4 Publications Citing Use of MCE Gabexate mesylate

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Description

In Vitro

Gabexate mesylate (FOY; 100-1000 μM; 72 hours) decreases The proliferation rate in a dose-dependent manner^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	HepG2 cells
Concentration:	100, 300, and 1000 μM
Incubation Time:	72 hours
Result:	The proliferation rate decreased in a dose-dependent manner.

In Vivo

Gabexate mesylate (FOY; 20 mg/kg; Intraperitoneally; daily; from 3rd day until the 14th day) attenuates the development of mechanical allodynia induced by spinal nerve ligation (SNL). Gabexate mesylate has an inhibitory effect on the expressions of pro-inflammatory cytokines after SNL for a short-term period^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (100-120 g) with spinal nerve ligation (SNL)^[4]
Dosage:	20 mg/kg
Administration:	Intraperitoneally; daily; from 3rd day until the 14th day
Result:	Showed a higher PWT than those of the vehicle-treated group. Markedly decreased the expression of p65. Attenuated the expressions of IL-1, IL-6, and TNF-α at 7th day.

Molecular Weight

417.48

Formula

C₁₇H₂₇N₃O₇S

CAS No.

56974-61-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC)C1=CC=C(OC(CCCCCNC(N)=N)=O)C=C1.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (239.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 7.14 mg/mL (17.10 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3953 mL	11.9766 mL	23.9532 mL
5 mM	0.4791 mL	2.3953 mL	4.7906 mL
10 mM	0.2395 mL	1.1977 mL	2.3953 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.99 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 130 mg/mL (311.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.14%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (245 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. H Ohno, et al. FOY: [ethyl P-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb Res. 1980;19(4-5):579-88. [Content Brief]

[2]. F Erba, et al. Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol. 2001 Feb 1;61(3):271-6. [Content Brief]

[3]. Tsuneo Ozeki, et al. The specific inhibition of HepG2 cells proliferation by apoptosis induced by gabexate mesilate. Int J Clin Exp Pathol. 2010 Aug 15;3(7):710-7. [Content Brief]

[4]. Seon Hee Oh, et al. Gabexate mesilate ameliorates the neuropathic pain in a rat model by inhibition of proinflammatory cytokines and nitric oxide pathway via suppression of nuclear factor-κB. Korean J Pain. 2020 Jan 1;33(1):30-39. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.3953 mL	11.9766 mL	23.9532 mL	59.8831 mL
	5 mM	0.4791 mL	2.3953 mL	4.7906 mL	11.9766 mL
	10 mM	0.2395 mL	1.1977 mL	2.3953 mL	5.9883 mL
	15 mM	0.1597 mL	0.7984 mL	1.5969 mL	3.9922 mL
DMSO	20 mM	0.1198 mL	0.5988 mL	1.1977 mL	2.9942 mL
	25 mM	0.0958 mL	0.4791 mL	0.9581 mL	2.3953 mL
	30 mM	0.0798 mL	0.3992 mL	0.7984 mL	1.9961 mL
	40 mM	0.0599 mL	0.2994 mL	0.5988 mL	1.4971 mL
	50 mM	0.0479 mL	0.2395 mL	0.4791 mL	1.1977 mL
	60 mM	0.0399 mL	0.1996 mL	0.3992 mL	0.9981 mL
	80 mM	0.0299 mL	0.1497 mL	0.2994 mL	0.7485 mL
	100 mM	0.0240 mL	0.1198 mL	0.2395 mL	0.5988 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Gabexate mesylate Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Gabexate mesylate (Synonyms: FOY)

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Other Forms of Gabexate mesylate:

Gabexate mesylate Related Antibodies

4 Publications Citing Use of MCE Gabexate mesylate

Featured Recommendations

•Related Screening Libraries:

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Purity & Documentation

References

Customer Review

Gabexate mesylate Related Antibodies

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Complete Stock Solution Preparation Table

Gabexate mesylate Related Classifications

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