2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Mitochondrial Metabolism
  4. Kresoxim-methyl

Kresoxim-methyl  (Synonyms: BAS 490 F)

Cat. No.: HY-125776 Purity: ≥99.0%
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Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme.

For research use only. We do not sell to patients.

Kresoxim-methyl Chemical Structure

Kresoxim-methyl Chemical Structure

CAS No. : 143390-89-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Kresoxim-methyl:

Kresoxim-methyl Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme[1][2].

In Vitro

Kresoxim-methyl affects antioxidant response, mitochondrial function and motility of neuroblastoma N2a cells upon 24h exposure[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kresoxim-methyl Related Antibodies
Molecular Weight

313.35

Formula

C18H19NO4
CAS No.
Appearance

Liquid (Density: 1.28 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC)/C(C1=CC=CC=C1COC2=CC=CC=C2C)=N/OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (319.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1913 mL 15.9566 mL 31.9132 mL
5 mM 0.6383 mL 3.1913 mL 6.3826 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1913 mL 15.9566 mL 31.9132 mL 79.7830 mL
5 mM 0.6383 mL 3.1913 mL 6.3826 mL 15.9566 mL
10 mM 0.3191 mL 1.5957 mL 3.1913 mL 7.9783 mL
15 mM 0.2128 mL 1.0638 mL 2.1275 mL 5.3189 mL
20 mM 0.1596 mL 0.7978 mL 1.5957 mL 3.9891 mL
25 mM 0.1277 mL 0.6383 mL 1.2765 mL 3.1913 mL
30 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6594 mL
40 mM 0.0798 mL 0.3989 mL 0.7978 mL 1.9946 mL
50 mM 0.0638 mL 0.3191 mL 0.6383 mL 1.5957 mL
60 mM 0.0532 mL 0.2659 mL 0.5319 mL 1.3297 mL
80 mM 0.0399 mL 0.1995 mL 0.3989 mL 0.9973 mL
100 mM 0.0319 mL 0.1596 mL 0.3191 mL 0.7978 mL
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Kresoxim-methyl Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kresoxim-methyl143390-89-0BAS 490 FFungalMitochondrial MetabolismfungicidefungaloomycetepathogensmitochondriastrobilurinInhibitorinhibitorinhibit

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