2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. Potassium Channel Endogenous Metabolite
  4. L-Palmitoylcarnitine

L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

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L-Palmitoylcarnitine Chemical Structure

L-Palmitoylcarnitine Chemical Structure

CAS No. : 2364-67-2

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Other Forms of L-Palmitoylcarnitine:

L-Palmitoylcarnitine Related Antibodies

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Description

L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].

IC50 & Target[1]

Kir6.2

 

Human Endogenous Metabolite

 

In Vitro

L-Palmitoylcarnitine (1 µM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC50 fell from 62 to 30 µM)[1].
Modulation of the membrane lipid environment caused by L-Palmitoylcarnitine alters the KATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Palmitoylcarnitine Related Antibodies
Molecular Weight

399.61

Formula

C23H45NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.4%

SDS (393 KB)

COA (240 KB)

Handling Instructions (2659 KB)
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L-Palmitoylcarnitine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Palmitoylcarnitine2364-67-2Potassium ChannelEndogenous MetaboliteKcsAfattyacidmetaboliteischaemialipidInhibitorinhibitorinhibit

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