2. Apoptosis
  3. Bcl-2 Family
  4. PUMA BH3

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PUMA BH3 Chemical Structure

PUMA BH3 Chemical Structure

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1 mg USD 70 In-stock
5 mg USD 200 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PUMA BH3:

PUMA BH3 Related Antibodies

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • Biological Activity

  • Purity & Documentation

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Description

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.

IC50 & Target[1]

Bak

26 nM (Kd)

In Vitro

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM. PUMA BH3 binds Bak in the canonical BH3-binding groove, and activates Bak[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PUMA BH3 Related Antibodies
Molecular Weight

2384.63

Formula

C100H162N34O32S
Appearance

Solid

Color

White to off-white

Sequence

Ac-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-NH2
Sequence Shortening

Ac-EQWAREIGAQLRRMADDLNA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (41.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4194 mL 2.0968 mL 4.1935 mL
5 mM 0.0839 mL 0.4194 mL 0.8387 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4194 mL 2.0968 mL 4.1935 mL 10.4838 mL
5 mM 0.0839 mL 0.4194 mL 0.8387 mL 2.0968 mL
10 mM 0.0419 mL 0.2097 mL 0.4194 mL 1.0484 mL
15 mM 0.0280 mL 0.1398 mL 0.2796 mL 0.6989 mL
20 mM 0.0210 mL 0.1048 mL 0.2097 mL 0.5242 mL
25 mM 0.0168 mL 0.0839 mL 0.1677 mL 0.4194 mL
30 mM 0.0140 mL 0.0699 mL 0.1398 mL 0.3495 mL
40 mM 0.0105 mL 0.0524 mL 0.1048 mL 0.2621 mL
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PUMA BH3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PUMA BH3PUMA BH 3PUMA BH-3Bcl-2 FamilyInhibitorinhibitorinhibit

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