Lumichrome 

Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway^[1][2].

Lumichrome (0-100 μM, 24 h) exhibits cytotoxicity in cancer cells H292, A549 and H460 (IC₅₀ = 38, 54 and 79 μM, respectively), induces apoptosis in these cells, and inhibits the colony formation^[2].
Lumichrome (0-10 μM, 5-28 days) inhibits RANKL-induced osteoclastogenesis and bone resorption through inhibition of NFAT/NF-κB/MAPK/calcium signaling pathways^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lumichrome (7.5 mg/kg, ip, three times a week for 6 weeks) reduces bone loss and prevents osteoporosis in the ovariectomized (OVX) mouse model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

242.24

C₁₂H₁₀N₄O₂

1086-80-2

Solid

Light yellow to yellow

O=C(N1)NC2=NC3=CC(C)=C(C)C=C3N=C2C1=O

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

• [1]. Bergh VJ, et al. Influence of formulation on photoinactivation of bacteria by lumichrome. Pharmazie. 2015;70(9):574-580.  [Content Brief]

  [2]. Chantarawong W, et al. Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53-Dependent Mechanism. Nutr Cancer. 2019;71(8):1390-1402.  [Content Brief]

  [3]. Liu C, et al., Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL-induced NFAT activation and calcium signaling. J Cell Physiol. 2018 Nov;233(11):8971-8983.  [Content Brief]