Palonosetron hydrochloride

Name: Palonosetron hydrochloride
Brand: MedChemExpress
SKU: HY-A0021
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0021 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity.

For research use only. We do not sell to patients.

Palonosetron hydrochloride Chemical Structure

CAS No. : 135729-62-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
200 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Palonosetron hydrochloride:

(R,R)-Palonosetron Hydrochloride Get quote
Palonosetron-d₃ hydrochloride Get quote
Palonosetron Get quote
Palonosetron hydrochloride (Standard) Get quote

1 Publications Citing Use of MCE Palonosetron hydrochloride

•PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. [Abstract]

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•Related Screening Libraries:

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View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

5-HT₃ Receptor

In Vitro

Palonosetron (10 nM, 2 hours) inhibits the enhancement effect of 5-HT on substance P (SP)-induced calcium release in NG108-15 cells, increasing the EC₅₀ of SP from 0.62 µM to 3.7 µM^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Palonosetron (0.05 mg/kg, i.p., single dose) significantly reduces immobility in Swiss albino mice, demonstrating potential antidepressant activity^[5].
alonosetron (30-300 µg/kg, i.v., single dose) dose-dependently inhibits SP-mediated neuronal responses in the Cisplatin (HY-17394)-induced rat emesis model, indicating its impact on neurotransmission^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss albino mice (25-40 g)^[5]
Dosage:	0.025 and 0.05 mg/kg
Administration:	Intraperitoneal injection (i.p.), single dose, efficacy tested after 1 hour and 24 hours
Result:	Reduced immobility time in a dose-dependent manner. The 0.05 mg/kg dose significantly reduced immobility time after 1 hour and 24 hours.

Animal Model:	Cisplatin-induced emesis model in adult male Sprague-Dawley rats (270-350 g)^[6]
Dosage:	30 µg/kg, 100 µg/kg, 300 µg/kg
Administration:	Intravenous injection (i.v.), single dose
Result:	Dose-dependently inhibited the Cisplatin (HY-17394)-induced enhancement of neuronal response to substance P (SP) in the nodose ganglia.

Clinical Trial

Molecular Weight

332.87

Formula

C₁₉H₂₅ClN₂O

CAS No.

135729-62-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C[C@@]([H])(CCC2)C3=C2C=CC=C13)[C@@H]4CN5CCC4CC5.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (300.42 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (10.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0042 mL	15.0209 mL	30.0418 mL
5 mM	0.6008 mL	3.0042 mL	6.0084 mL
10 mM	0.3004 mL	1.5021 mL	3.0042 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 0.33 mg/mL (0.99 mM); Clear solution

This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 0.33 mg/mL (0.99 mM); Clear solution

This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 0.33 mg/mL (0.99 mM); Clear solution

This protocol yields a clear solution of ≥ 0.33 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (3.3 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (300.42 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (286 KB) SDS (393 KB)

COA (260 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Barrows, et al. "A screen of FDA-approved drugs for inhibitors of Zika virus infection." Cell host & microbe 20.2 (2016): 259-270. [Content Brief]

[2]. Rojas, et al. "Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor." Anesthesia & Analgesia 107.2 (2008): 469-478. [Content Brief]

[3]. Wallenborn, et al. "Palonosetron hydrochloride in the prevention and treatment of postoperative nausea and vomiting." Clinical Medicine Insights: Therapeutics 2 (2010): CMT-S4016.

[4]. Sepúlveda-Vildósola, et al. "Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy-induced nausea and vomiting in children." Archives of medical research 39.6 (2008): 601-606. [Content Brief]

[5]. Sharma J, et al. Evaluation of antidepressant effect of palonosetron in Swiss albino mice[J]. National Journal of Pharmacology and Therapeutics, 2023, 1(2): 98-100.

[6]. Rojas C, et al. The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo. J Pharmacol Exp Ther. 2010 Nov;335(2):362-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.0042 mL	15.0209 mL	30.0418 mL	75.1044 mL
DMSO / H₂O	5 mM	0.6008 mL	3.0042 mL	6.0084 mL	15.0209 mL
H₂O	15 mM	0.2003 mL	1.0014 mL	2.0028 mL	5.0070 mL
	20 mM	0.1502 mL	0.7510 mL	1.5021 mL	3.7552 mL
	25 mM	0.1202 mL	0.6008 mL	1.2017 mL	3.0042 mL
	30 mM	0.1001 mL	0.5007 mL	1.0014 mL	2.5035 mL
	40 mM	0.0751 mL	0.3755 mL	0.7510 mL	1.8776 mL
	50 mM	0.0601 mL	0.3004 mL	0.6008 mL	1.5021 mL
	60 mM	0.0501 mL	0.2503 mL	0.5007 mL	1.2517 mL
	80 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.9388 mL
	100 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7510 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.