Phenylacetylglutamine (Synonyms: NSC 203800; Phenylacetyl-L-glutamine)

Name: Phenylacetylglutamine
Brand: MedChemExpress
SKU: HY-W050026
Rating: 4.5 (1 reviews)

Cat. No.: HY-W050026 Purity: 97.92%: FAQs
Data Sheet SDS COA Handling Instructions

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Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

For research use only. We do not sell to patients.

Phenylacetylglutamine Chemical Structure

CAS No. : 28047-15-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
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5 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
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200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phenylacetylglutamine:

Phenylacetylglutamine-d₅ Get quote

1 Publications Citing Use of MCE Phenylacetylglutamine

•Biomolecules. 2022, 12(8), 1120.

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Description

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation. It results from glutamine conjugation of phenylacetic acid, which is almost exclusively derived from the microbial conversion of phenylalanine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

264.28

Formula

C₁₃H₁₆N₂O₄

CAS No.

28047-15-6

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H](CCC(N)=O)NC(CC1=CC=CC=C1)=O)O

Structure Classification

Amino acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (378.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (94.60 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7839 mL	18.9193 mL	37.8387 mL
5 mM	0.7568 mL	3.7839 mL	7.5677 mL
10 mM	0.3784 mL	1.8919 mL	3.7839 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (7.87 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (189.19 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.02%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Poesen R, et al. Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD. J Am Soc Nephrol. 2016 Nov;27(11):3479-3487. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.7839 mL	18.9193 mL	37.8387 mL	94.5966 mL
	5 mM	0.7568 mL	3.7839 mL	7.5677 mL	18.9193 mL
	10 mM	0.3784 mL	1.8919 mL	3.7839 mL	9.4597 mL
	15 mM	0.2523 mL	1.2613 mL	2.5226 mL	6.3064 mL
	20 mM	0.1892 mL	0.9460 mL	1.8919 mL	4.7298 mL
	25 mM	0.1514 mL	0.7568 mL	1.5135 mL	3.7839 mL
	30 mM	0.1261 mL	0.6306 mL	1.2613 mL	3.1532 mL
	40 mM	0.0946 mL	0.4730 mL	0.9460 mL	2.3649 mL
	50 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8919 mL
	60 mM	0.0631 mL	0.3153 mL	0.6306 mL	1.5766 mL
	80 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1825 mL
DMSO	100 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9460 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Phenylacetylglutamine Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylacetylglutamine28047-15-6NSC 203800 Phenylacetyl-L-glutamineNSC203800NSC-203800Endogenous MetaboliteInhibitorinhibitorinhibit

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Phenylacetylglutamine (Synonyms: NSC 203800; Phenylacetyl-L-glutamine)

Customer Review

Other Forms of Phenylacetylglutamine:

Phenylacetylglutamine Related Antibodies

1 Publications Citing Use of MCE Phenylacetylglutamine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Phenylacetylglutamine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Phenylacetylglutamine Related Classifications

Keywords:

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