Dopamine Receptor Antagonist

Dopamine Receptor Antagonists (188):

Cat. No.	Product Name	Effect	Purity

HY-B0031R

Quetiapine (hemifumarate) (Standard)	Antagonist	99.87%
Quetiapine (hemifumarate) (Standard) is the analytical standard of Quetiapine (hemifumarate). This product is intended for research and analytical applications. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.

HY-135497

Fallypride	Antagonist	99.93%
Fallypride is a potent antagonist of dopamine D2/D3 receptor. Fallypride, in the form of fallypride (¹⁸F), can be used as a positron emission tomography (PET) radiotracer.

HY-103405

NGD94-1	Antagonist	99.73%
NGD94-1 is a specific dopamine D₄ receptor antagonist. NGD94-1 can effectively reverse Phencyclidine-induced cognitive impairment in marmosets. NGD94-1 can be used in the study of psychiatric diseases.

HY-129059

Odapipam	Antagonist	≥99.0%
Odapipam (NNC 756) is a selective, high affinity and benzazepine dopamine D₁ receptor antagonist with a K_d of 0.18 nM. Odapipam is also a superior positron emission tomography (PET) radiotracer.

HY-158243

Fallypride precursor	Antagonist	98.92%
Fallypride precursor (Compound 15) can be used for synthesis of Fallypride (HY-135497). Fallypride is an antagonist of the dopamine D2/D3 receptor. Fallypride can be used as a positron emission tomography (PET) radiotracer when labeled with ¹⁸F.

HY-B1164

Bromopride	Antagonist	99.87%
Bromopride is a dopamine antagonist with prokinetic properties, widely used as an antiemetic.

HY-111066A

JNJ-37822681 dihydrochloride	Antagonist	99.41%
JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D₂ receptor antagonist with a moderate binding affinity for the dopamine D_2L receptor (K_i =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder.

HY-14545A

Amisulpride hydrochloride	Antagonist	99.79%
Amisulpride hydrochloride is a dopamine D₂/D₃ receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D₂ and D₃, respectively.

HY-100649

Hydroxy ziprasidone	Antagonist	99.53%
Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.

HY-A0163S

Zuclopenthixol-d₄ succinate	Antagonist	≥99.0%
Zuclopenthixol-d₄ (succinate) is the deuterium labeled Zuclopenthixol. Zuclopenthixol is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist[1][2].

HY-B0031S

Quetiapine-d₄ fumarate	Antagonist	≥98.0%
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-14538B

Haloperidol lactate	Antagonist
Haloperidol lactate is a potent antipsychotic agent. Haloperidol lactate can be used in acute and chronic schizophrenia and gilles de la tourette's syndrome. Haloperidol lactate has the potential for the research of psychotic disorders.

HY-14543S

Sertindole-d₄	Antagonist	98.64%
Sertindole-d₄ is the deuterium labeled Sertindole. Sertindole, a neuroleptic, is one of the newer antipsychotic medications available[1][2].

HY-109150A

Mesdopetam hemitartrate	Antagonist	99.86%
Mesdopetam (IRL790) hemitartrate is a dopamine D3 receptor antagonist (K_i=90 nM; IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam hemitartrate is used for the research of motor and psychiatric complications in Parkinson disease.

HY-109167

Aramisulpride	Antagonist	99.49%
Aramisulpride is a dopamine D2 receptor and serotonin receptor antagonist used for the research of metabolic disorders.

HY-12701A

U-99194 maleate	Antagonist	99.23%
U-99194 maleate is a potent and selective Dopamine3 Receptor (D3 receptor) antagonist. U-99194 maleate also enhances prolactin secretion and striatal dopamine synthesis.

HY-B2089

Cinitapride	Antagonist	98.24%
Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research.

HY-14539S2

Clozapine-d₄	Antagonist	99.82%
Clozapine-d₄ is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].

HY-101797

Veralipride	Antagonist	99.57%
Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.

HY-A0125

Alizapride	Antagonist
Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders.

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