Leukotriene Receptor

Leukotriene Receptor Related Products (110):

By Effects:	Control (1) Inhibitors (34) Agonists (6) Antagonists (52) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-14166

MK-886	Inhibitor	99.77%
MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC₅₀ of 30 nM) and leukotriene biosynthesis (IC₅₀s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis.

HY-B0174

Olsalazine Disodium		99.89%
Olsalazine Disodium is an anti-inflammatory compound that works in inflammatory bowel disease and ulcerative colitis.

HY-B0174A

Olsalazine	Inhibitor	99.83%
Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity.

HY-76511

Verlukast		98.61%
Verlukast is a potent, selective, and orally active antagonist of leukotriene receptor. Verlukast has the potential for the research of asthma.

HY-105484

U-75302	Inhibitor	≥99.0%
U-75302 is a potent inhibitor of leukotriene B4. U-75302 is a pyridine analogue. U-75302 has the potential for the research of inflammatory diseases.

HY-164650

Pirodomast	Inhibitor
Pirodomast (Sch 37224) is a leukotriene formation inhibitor. Pirodomast inhibits LTD4 andthromboxane B2 release by anaphylactic guinea pig lung with the IC₅₀ values of 3.9 and 1.9 μM, respectively. Pirodomast can be used for study of asthma.

HY-P3318

Boc-Phe-Leu-Phe-Leu-Phe	Antagonist	98.03%
Boc-Phe-Leu-Phe-Leu-Phe, a chemotactic peptide antagonist, abolishes the FMLP-induced release of peptide leukotrienes.

HY-N15230

Torososide B
Torososide B is an antiallergic compound that inhibits calcium ionophore A-induced leukotriene release from rat peritoneal mast cells.

HY-108396

γ-Linolenic acid ethyl ester	Antagonist	99.14%
γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B₄ receptor 4 (LTB₄) antagonist.

HY-108693

β-Tocotrienol		98.89%
β-Tocotrienol is one form of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol.

HY-111212

Tomelukast	Antagonist	≥99.0%
Tomelukast (LY171883) is an orally active leukotriene D₄ and E₄ antagonist. Tomelukast can be used for the research of asthma.

HY-106929

Moxilubant	Antagonist	99.83%
Moxilubant (CGS-25019C;LTB-019) is an orally active BLT1 antagonist which inhibits LTB4 signaling with a potency of 2–4 nM. Moxilubant can be used for cancer research.

HY-101676

RG-12525	Antagonist	98.31%
RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC₅₀s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC₅₀ of appr 60 nM and a potent inhibitor of CYP3A4, with a K_i value of 0.5 µM.

HY-156978

Ritolukast	Antagonist	99.92%
Ritolukast (Wy-48252) is an orally active aerosol leukotriene (LTD₄/E₄) receptor antagonist. Ritolukast can be used to inhibit the bronchoconstriction caused by aerosol LTD₄ in guinea pigs, with an ID₅₀ of 0.5mg/kg.

HY-13315S1

Montelukast-d₆ sodium	Antagonist
Montelukast-d₆ (sodium) is the deuterium labeled Montelukast (sodium). Montelukast sodium is a potent, selective and orally active antagonist of cysteinyl leukotriene receptor 1 (Cysltr1). Montelukast sodium can be used for the reseach of asthma and liver injury. Montelukast sodium also has an antioxidant effect in intestinal ischemia-reperfusion injury, and could reduce cardiac damage[1].

HY-107610

SR2640 hydrochloride	Antagonist	99.60%
SR2640 (hydrochloride) is a potent and selective competitive leukotriene D4/leukotriene E4 antagonist. SR2640 can be used for researching the role of leukotrienes in human asthma.

HY-101438

Darbufelone	Inhibitor	≥98.0%
Darbufelone is a dual inhibitor of cellular PGF_2α and LTB₄ production. Darbufelone potently inhibits PGHS-2 (IC₅₀= 0.19 μM) but is much less potent with PGHS-1 (IC₅₀=20 μM).

HY-149589

11(Z),14(Z)-Eicosadienoic acid	Inhibitor	≥98.0%
11(Z),14(Z)-Eicosadienoic acid is a unsaturated fattly acid that inhibits [³H] leukotriene B₄ (LTB₄) binding to pig neutrophil membranes with a K_i of 3 μM. 11(Z),14(Z)-Eicosadienoic acid has inflammatory activities.

HY-145234

GPBAR1-IN-3	Antagonist
GPBAR1-IN-3 (Compound 14) is a selective GPBAR1 agonist (EC₅₀=0.17 μM) and a CysLT₁R antagonist.

HY-105221

Masilukast	Antagonist
Masilukast is an orally administered cysteinyl leukotriene D₄ (LTD₄) receptor antagonist with potential to research asthma.

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