2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. JNJ-61803534

JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6  nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions.

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JNJ-61803534 Chemical Structure

JNJ-61803534 Chemical Structure

CAS No. : 1917306-14-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1027 In-stock
Solution
10 mM * 1 mL in DMSO USD 1027 In-stock
Solid
1 mg USD 300 In-stock
5 mg USD 750 In-stock
10 mg USD 1200 In-stock
25 mg USD 2400 In-stock
50 mg USD 3800 In-stock
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Based on 1 publication(s) in Google Scholar

JNJ-61803534 Related Antibodies

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Description

JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6  nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions[1].

IC50 & Target[1]

RORγt

 

In Vitro

JNJ-61803534 inhibits RORγt transcription in HEK-293 T cells transfected with vectors encoding RORγt, with an IC50 of 9.6  nM[1].
JNJ-61803534 (1 nM-1 μM) inhibits IL-17A, IL-17F IFNγ and IL-22 production in CD4+ T cells isolated from human blood[1].
JNJ-61803534 does not impact in vitro Treg differentiation in CD4+ T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-61803534 Related Antibodies
In Vivo

JNJ-61803534 (100 mg/kg, p.o.) inhibits ex vivo stimulated IL-17A production in the blood of mice[1].
JNJ-61803534 (3-100 mg/kg BID or 60 mg/kg QD, p.o.) alleviates inflammation, cartilage damage, bone destruction in mouse collagen-induced arthritis (CIA) model[1].
JNJ-61803534 (30 and 100 mg/kg, p.o.) alleviates Imiquimod (HY-B0180)-induced dermal psoriatic-like inflammation in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse collagen-induced arthritis (CIA) model[1]
Dosage: 3-100 mg/kg BID or 60 mg/kg QD
Administration: Oral administration (p.o.)
Result: Decreased clinical arthritis scores and hind paw histopathology scores.
Molecular Weight

622.41

Formula

C23H23Cl2F6N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC(C(N2[C@H](C)CCC2)=O)=C(C3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C(Cl)=C3Cl)S1)NCC(C)(O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (482.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6067 mL 8.0333 mL 16.0666 mL
5 mM 0.3213 mL 1.6067 mL 3.2133 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6067 mL 8.0333 mL 16.0666 mL 40.1665 mL
5 mM 0.3213 mL 1.6067 mL 3.2133 mL 8.0333 mL
10 mM 0.1607 mL 0.8033 mL 1.6067 mL 4.0166 mL
15 mM 0.1071 mL 0.5356 mL 1.0711 mL 2.6778 mL
20 mM 0.0803 mL 0.4017 mL 0.8033 mL 2.0083 mL
25 mM 0.0643 mL 0.3213 mL 0.6427 mL 1.6067 mL
30 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.3389 mL
40 mM 0.0402 mL 0.2008 mL 0.4017 mL 1.0042 mL
50 mM 0.0321 mL 0.1607 mL 0.3213 mL 0.8033 mL
60 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.6694 mL
80 mM 0.0201 mL 0.1004 mL 0.2008 mL 0.5021 mL
100 mM 0.0161 mL 0.0803 mL 0.1607 mL 0.4017 mL
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JNJ-61803534 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-618035341917306-14-9JNJ61803534JNJ 61803534RORRAR-related orphan receptorCollagen-induced arthritisCIAanti-inflammatoryTh17CD4+ T cellIL-17AInhibitorinhibitorinhibit

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