Topo II

Topo II Related Products (111):

By Type:	Pan (29) Selective (57)

Cat. No.	Product Name	Effect	Purity

HY-153401

Topoisomerase II inhibitor 13	Inhibitor	99.26%
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis.

HY-146138

EGFR-IN-57	Inhibitor
EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC₅₀ of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC₅₀ values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis.

HY-146020

Topoisomerase IIα-IN-1	Inhibitor
Topoisomerase IIα-IN-1 (compound 2) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-1 exhibits high antiproliferative activity against human cancer cell lines.

HY-W031307

Topoisomerase IIα-IN-8	Inhibitor
Topoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC₅₀ of 462 ± 38.0 μM.

HY-109855

CP-67015	Inhibitor
CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects.

HY-161628

Tapcin	Inhibitor
Tapcin is a dual inhibitor for topoisomerase I and topoisomerase II, with IC₅₀ of 203 and 71 nM. Tapcin inhibits proliferations of cancer cells A-375, HeLa, Huh7.5, U2-OS, A549, Caco-2 and HT29, with IC₅₀s of 441, 1.04, 40.5, 0.002, 0.006, 0.287 and 0.842 nM, respectively. Tapcin exhibits antitumor activity in HT29 xenograft model.

HY-163118

Topoisomerase II inhibitor 17	Inhibitor
Topoisomerase II inhibitor 17 (compound 4c) is an inhibitor of thiazolopyrimidine topoisomerase (Topoisomerase) Top II (IC₅₀: 0.23 μM). Topoisomerase II inhibitor 17 can significantly cause cell cycle disruption and apoptosis.

HY-143402

Topoisomerase I/II inhibitor 2	Inhibitor
Topoisomerase I/II inhibitor 2 (compound 1a) is a potent Topoisomerase inhibitor (IC₅₀= 9.82 μM on Huh7 cells and 6.83 μM on LM9 cells). Topoisomerase I/II inhibitor 2 has dual inhibition on DNA topoisomerase I/II, also can obviously reduce the growth of xenograft tumor in mice model. Topoisomerase I/II inhibitor 2 has the potential value in researching liver cancer.

HY-170912

Topo I/II-IN-2	Inhibitor
Topo I/II-IN-2 (Compound 3g) is an inhibitor of Topo I and Topo II. Topo I/II-IN-2 inhibits NCI-H446 cells and NCI-H1048 cells with IC₅₀s of 1.30 μM and 1.42 μM, respectively. Topo I/II-IN-2 induces mitochondrial Apoptosis, mitochondrial dysfunction and activity generation. Topo I/II-IN-2 inhibits the PI3K/Akt/mTOR pathway. Topo I/II-IN-2 prevents SCLC (small cell lung cancer) cell proliferation, invasion, and migration in vitro. .

HY-120185

Saintopin	Inhibitor
Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage.

HY-101647A

Intoplicine dimesylate	Inhibitor	98.28%
Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (K_A = 2 x 10⁵ /M) and thereby increases the length of linear DNA.

HY-146163

Topoisomerase II inhibitor 7	Inhibitor
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC₅₀ of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis.

HY-169628

Topoisomerase I/II inhibitor 7	Inhibitor
Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor.

HY-152479

Topoisomerase IIα-IN-7	Inhibitor
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC₅₀ value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability.

HY-124552

Epolactaene	Inhibitor
Epolactaene is a potent Topoisomerase II and DNA Polymerase inhibitor with IC₅₀ values of 10, 25, 94 µM for Topoisomerase II, DNA Polymerase α, DNA Polymerase β, respectively.

HY-162381

Topoisomerase II inhibitor 19	Inhibitor
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and topoisomerase II inhibitor (IC₅₀ value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA.

HY-N10367

Corydamine	Inhibitor
Corydamine, 3-arylisoquinoline alkaloid, is a potent DNA topoisomerase I/II inhibitor. Corydamine has anti-cancer activity.

HY-150045

TP0480066	Inhibitor
TP0480066 is a selective topoisomerase II inhibitor with IC₅₀s of 1.10 and 62.89 nM for DNA gyrase and topo IV, respectively. TP0480066 shows good activity of againsting various bacterial species including drug-resistant strains. TP0480066 also exhibits potent inhibitory activity to N. gonorrhoeae, can be used in study of gonorrhea.

HY-12888

AZD5099	Inhibitor
AZD5099, an antibacterial agent, is a potent and selective bacterial topoisomerase II inhibitor. AZD5099 potently inhibits the infections caused by Gram-positive and fastidious Gram-negative bacteria.

HY-146188

Topoisomerase II inhibitor 8	Inhibitor
Topoisomerase II inhibitor 8 (compound 22) is a potent topoisomerase II inhibitor, with an IC₅₀ of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase.

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