mAChR Inhibitor

mAChR Inhibitors (55):

Cat. No.	Product Name	Effect	Purity

HY-A0016

Dronedarone	Inhibitor	99.93%
Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.

HY-B0499A

Otilonium bromide	Inhibitor	99.69%
Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome.

HY-13204A

Biperiden	Inhibitor	99.65%
Biperiden (KL 373) is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden has the potential for the research of Parkinson's disease and other related psychiatric disorders.

HY-B0416

Gallamine Triethiodide	Inhibitor	≥98.0%
Gallamine Triethiodide is a cholinergic receptor inhibitor and non-depolarizing blocker with an IC50 of 68.0±8.4 μM.

HY-107416

RHC 80267	Inhibitor	98.08%
RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL) (with IC₅₀ of 4 μM in canine platelets). RHC-80267 inhibits cholinesterase activity with an IC₅₀ of 4 μM, thereby enhancing the relaxation evoked by acetylcholine. RHC 80267 also inhibits COX and the hydrolysis of phosphatidylcholine (PC).

HY-116408A

Propiverine hydrochloride	Inhibitor	99.89%
Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.

HY-P1376A

G-Protein antagonist peptide TFA	Inhibitor	98.91%
G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of G_i or G_o by M2 muscarinic cholinergic receptor (M2 mAChR) or of G_s by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis.

HY-100795A

Pirmenol hydrochloride	Inhibitor	99.34%
Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I_K.ACh (IC₅₀: 0.1 μM) by blocking mAchR. Pirmenol hydrochloride can be used in the research of cardiovascular disease, such as atrial fibrillation.

HY-B2070

Methylbenactyzium Bromide	Inhibitor	99.76%
Methylbenactyzium Bromide is a muscarinic acetylcholine receptor (mAChR) inhibitor.

HY-101858

BQCA	Inhibitor	98.38%
BQCA a highly selective allosteric modulator of the M1 mAChR.

HY-13204

Biperiden hydrochloride	Inhibitor	99.90%
Biperiden (KL 373) hydrochloride is a non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors, thereby inhibiting acetylcholine and enhancing dopamine signaling in the central nervous system. Biperiden hydrochloride has the potential for the research of Parkinson's disease and other related psychiatric disorders.

HY-B0527AS

Amitriptyline-d₆ hydrochloride	Inhibitor	99.65%
Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-113995

(-)-Vesamicol	Inhibitor	98.09%
(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC₅₀ of 75 nM. (-)-Vesamicol can be used for release and recycling of synaptic vesicles study.

HY-N7004

Arborine	Inhibitor	99.80%
Arborine inhibits the peripheral action of acetylcholine and induces a fall in blood pressure.

HY-135096

Amitriptyline-d3 hydrochloride	Inhibitor	99.46%
Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.

HY-B0962

Piperidolate hydrochloride	Inhibitor	99.66%
Piperidolate hydrochloride is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).

HY-B0962A

Piperidolate	Inhibitor	99.71%
Piperidolate is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs).

HY-105545A

Levetimide	Inhibitor	99.96%
Levetimide is a potent and stereoselective inhibitor of [³H](+)pentazocine binding, with a K_i of 2.2 nM.

HY-B1188S

Propantheline-d₃ bromide	Inhibitor	99.00%
Propantheline-d₃ (bromide) is the deuterium labeled Propantheline bromide. Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

HY-B1230

Camylofine	Inhibitor
Camylofin is an antimuscarinic, is a smooth muscle relaxant .

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