2. Apoptosis
  3. MDM-2/p53
  4. Tenovin-3

Tenovin-3 is a p53 activator.

For research use only. We do not sell to patients.

Tenovin-3 Chemical Structure

Tenovin-3 Chemical Structure

CAS No. : 1011301-27-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 176 In-stock
Solution
10 mM * 1 mL in DMSO USD 176 In-stock
Solid
1 mg USD 70 In-stock
5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 440 In-stock
50 mg USD 650 In-stock
100 mg USD 945 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Tenovin-3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tenovin-3 is a p53 activator[1][2].

Cellular Effect
Cell Line Type Value Description References
Vero EC50
2.27 μM
Compound: 20r
Antiviral activity against La Crosse virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by fluorometric analysis
Antiviral activity against La Crosse virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by fluorometric analysis
[PMID: 22664128]
In Vitro

Tenovin-3 downregulates both P-FAK and P-Src[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tenovin-3 Related Antibodies
Molecular Weight

327.44

Formula

C18H21N3OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(NC1=CC=C(N)C=C1)=S)C2=CC=C(C(C)(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (94.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0540 mL 15.2700 mL 30.5399 mL
5 mM 0.6108 mL 3.0540 mL 6.1080 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.63 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (245 KB) HNMR (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0540 mL 15.2700 mL 30.5399 mL 76.3499 mL
5 mM 0.6108 mL 3.0540 mL 6.1080 mL 15.2700 mL
10 mM 0.3054 mL 1.5270 mL 3.0540 mL 7.6350 mL
15 mM 0.2036 mL 1.0180 mL 2.0360 mL 5.0900 mL
20 mM 0.1527 mL 0.7635 mL 1.5270 mL 3.8175 mL
25 mM 0.1222 mL 0.6108 mL 1.2216 mL 3.0540 mL
30 mM 0.1018 mL 0.5090 mL 1.0180 mL 2.5450 mL
40 mM 0.0763 mL 0.3817 mL 0.7635 mL 1.9087 mL
50 mM 0.0611 mL 0.3054 mL 0.6108 mL 1.5270 mL
60 mM 0.0509 mL 0.2545 mL 0.5090 mL 1.2725 mL
80 mM 0.0382 mL 0.1909 mL 0.3817 mL 0.9544 mL
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Tenovin-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tenovin-31011301-27-1Tenovin3Tenovin 3MDM-2/p53Inhibitorinhibitorinhibit

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