Terbuthylazine

Cat. No.: HY-B1847 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide.

For research use only. We do not sell to patients.

Terbuthylazine Chemical Structure

CAS No. : 5915-41-3

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 108	In-stock	Estimated Time of Arrival: December 31
1 g		Get quote
5 g		Get quote

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Other Forms of Terbuthylazine:

Terbuthylazine-d₅ Get quote
Terbuthylazine (Standard) Get quote

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Purity & Documentation
References
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Description

Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide.

Molecular Weight

229.71

Formula

C₉H₁₆ClN₅

CAS No.

5915-41-3

Appearance

Solid

Color

White to off-white

SMILES

CCNC1=NC(Cl)=NC(NC(C)(C)C)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (217.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3533 mL	21.7666 mL	43.5331 mL
5 mM	0.8707 mL	4.3533 mL	8.7066 mL
10 mM	0.4353 mL	2.1767 mL	4.3533 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (10.88 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (537 KB)

COA (246 KB) HNMR (285 KB)

Handling Instructions (2659 KB)

References

[1]. Cedergreen N, et al. Does the effect of herbicide pulse exposure on aquatic plants depend on Kow or mode of action? Aquat Toxicol. 2005 Feb 10;71(3):261-271. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.3533 mL	21.7666 mL	43.5331 mL	108.8329 mL
	5 mM	0.8707 mL	4.3533 mL	8.7066 mL	21.7666 mL
	10 mM	0.4353 mL	2.1767 mL	4.3533 mL	10.8833 mL
	15 mM	0.2902 mL	1.4511 mL	2.9022 mL	7.2555 mL
	20 mM	0.2177 mL	1.0883 mL	2.1767 mL	5.4416 mL
	25 mM	0.1741 mL	0.8707 mL	1.7413 mL	4.3533 mL
	30 mM	0.1451 mL	0.7256 mL	1.4511 mL	3.6278 mL
	40 mM	0.1088 mL	0.5442 mL	1.0883 mL	2.7208 mL
	50 mM	0.0871 mL	0.4353 mL	0.8707 mL	2.1767 mL
	60 mM	0.0726 mL	0.3628 mL	0.7256 mL	1.8139 mL
	80 mM	0.0544 mL	0.2721 mL	0.5442 mL	1.3604 mL
	100 mM	0.0435 mL	0.2177 mL	0.4353 mL	1.0883 mL

Terbuthylazine Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terbuthylazine5915-41-3Acetolactate Synthase (ALS)Acetohydroxyacid synthaseInhibitorinhibitorinhibit

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