2. Neuronal Signaling
  3. Amyloid-β
  4. Tramiprosate

Tramiprosate  (Synonyms: Homotaurine; 3-Amino-1-propanesulfonic acid)

Cat. No.: HY-14602 Purity: ≥98.0%
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Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects.

For research use only. We do not sell to patients.

Tramiprosate Chemical Structure

Tramiprosate Chemical Structure

CAS No. : 3687-18-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
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10 mM * 1 mL in Water USD 55 In-stock
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5 g USD 114 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tramiprosate:

Tramiprosate Related Antibodies

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Description

Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].

In Vitro

Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tramiprosate Related Antibodies
In Vivo

Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)[1]
Dosage: 50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
Administration: Intraperitoneal injection; once
Result: Dose-dependently reduced the infarct volume after MCAO.
Clinical Trial
Molecular Weight

139.17

Formula

C3H9NO3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCCS(=O)(O)=O
Structure Classification
Initial Source

red marine algae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (143.71 mM; Need ultrasonic)

DMSO : 1 mg/mL (7.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.1855 mL 35.9273 mL 71.8546 mL
5 mM 1.4371 mL 7.1855 mL 14.3709 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 140 mg/mL (1005.96 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (229 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 7.1855 mL 35.9273 mL 71.8546 mL 179.6364 mL
5 mM 1.4371 mL 7.1855 mL 14.3709 mL 35.9273 mL
H2O 10 mM 0.7185 mL 3.5927 mL 7.1855 mL 17.9636 mL
15 mM 0.4790 mL 2.3952 mL 4.7903 mL 11.9758 mL
20 mM 0.3593 mL 1.7964 mL 3.5927 mL 8.9818 mL
25 mM 0.2874 mL 1.4371 mL 2.8742 mL 7.1855 mL
30 mM 0.2395 mL 1.1976 mL 2.3952 mL 5.9879 mL
40 mM 0.1796 mL 0.8982 mL 1.7964 mL 4.4909 mL
50 mM 0.1437 mL 0.7185 mL 1.4371 mL 3.5927 mL
60 mM 0.1198 mL 0.5988 mL 1.1976 mL 2.9939 mL
80 mM 0.0898 mL 0.4491 mL 0.8982 mL 2.2455 mL
100 mM 0.0719 mL 0.3593 mL 0.7185 mL 1.7964 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tramiprosate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tramiprosate3687-18-1Homotaurine 3-Amino-1-propanesulfonic acidAmyloid-ββ-amyloid peptideAβAbetaNeuroprotectionanticonvulsionantihypertensionNMDAnNOSPSD95aminosulphonateAβ42Inhibitorinhibitorinhibit

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