2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis HDAC
  4. Triacetin

Triacetin  (Synonyms: Glyceryl triacetate; 1,2,3-Triacetoxypropane)

Cat. No.: HY-B0896 Purity: 99.58%
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Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid, orally active. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy .

For research use only. We do not sell to patients.

Triacetin Chemical Structure

Triacetin Chemical Structure

CAS No. : 102-76-1

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Other Forms of Triacetin:

Triacetin Related Antibodies

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Description

Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid, orally active. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Triacetin (0.25%, 24 h) induces growth arrest of HOG, Hs683, U87, U251, OG33, OG35 GBM9, GBM12, GBM34, GBM2, GBM8 and GBM44 cells in vitro[1].
Triacetin (25 mM, 24 h) causes effective inhibition on the U87MG (human malignant glioma) cell viability[2].
Triacetin (12.5-25 mM, 24 h) induces clear G2/M cell-cycle arrest in U87MG cells.[2].
Triacetin (12.5 mM) induces apoptosis in GBM cancer cells[2].
Triacetin (25 mM, 24 h) decreases the class I and class II HDAC (histone deacetylase) mRNA expression in U87MG cells[2].
Triacetin (12.5 mM, 24 h) inhibits HDAC-8 activity in U87MG cells[2].
Triacetin (12.5 mM, 24 h) activates the mTOR complexes downstream genes which play an important role in cancer cell metabolism such as S6K1, mSIN1, Protor 2, and PKCα[2].
Triacetin (12.5 mM, 24 h) shows an increased tumor suppressor miRs that can inhibit growth, proliferation, invasion, migration, and angiogenesis in U87MG cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Triacetin Related Antibodies

Cell Cycle Analysis[1]

Cell Line: Established glioma cell lines and primary tumor-derived GSCs.
Concentration: 0.25%
Incubation Time: 24 h
Result: Induced G0 growth arrest of all glioma cells, except U87, U251 and GBM (glioblastoma) 8 GSCs, without affecting Oli-Neu OPCs (oligodendrocyte progenitor cell line) or astrocytes and promoted NSC (neural stem cells) expansion.
The growth reduction of established glioma cell lines and primary tumor-derived GSCs in vitro is not due to the promotion of differentiation.

Cell Cycle Analysis[2]

Cell Line: U87 MG cells
Concentration: 12.5, 25 mM
Incubation Time: 24 h
Result: Induced 12% and 25% of sub-G1 cells and 60% and 79% of G2/M cells.

Apoptosis Analysis[2]

Cell Line: GBM cancer cells
Concentration: 12.5 mM
Incubation Time: 24 h
Result: Increased caspase-3 activity in treated GBM cancer cells.

RT-PCR[2]

Cell Line: U87MG cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Decreased the classI and class II HDAC (histone deacetylase) mRNA expression.
Increased expression of S6K1, mSIN1, Protor 2, and PKCα.
Increased expression of miR-15b, miR-92, miR-101, miR-155, miR-199, miR-200, miR-223, and slight increase in expression in miR-16 and miR-17.
In Vivo

Triacetin (5.0 g/kg with 10% v/v oral-sweet SF, p.o., daily, 14 days) enhances TMZ (Temozolomide) (HY-17364) chemotherapeutic efficacy in mice engrafted with oligodendroglioma-derived GSCs[1].
Triacetin (5.0 g/kg with 10% v/v Ora-Sweet SF, p.o., daily, 40days) alone increases survival of mice orthotopically engrafted with GBM-derived GSCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with oligodendroglioma-derived GSC cells [1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 14 days
Result: Significantly reduced tumor bioluminescence and increased survival but did not reduce end-point tumor volume with treatment of TMZ (Temozolomide) (HY-17364).
Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with GBM-derived GSC cells[1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 40 days
Result: Alone did not alter blood glucose, bioluminescence, or end-point tumor volume; however, increased survival.
Significantly increased survival with treatment of TMZ, with two of eight mice never redeveloping measurable flux or displaying histological signs of tumor at study termination.
Molecular Weight

218.20

Formula

C9H14O6
CAS No.
Appearance

Liquid (Density: 1.16 g/cm3)

Color

Colorless to light yellow

SMILES

CC(OCC(OC(C)=O)COC(C)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 2.3 mg/mL (10.54 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5830 mL 22.9148 mL 45.8295 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5830 mL 22.9148 mL 45.8295 mL 114.5738 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL 22.9148 mL
10 mM 0.4583 mL 2.2915 mL 4.5830 mL 11.4574 mL
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Triacetin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triacetin102-76-1Glyceryl triacetate 1,2,3-TriacetoxypropaneApoptosisHDACHistone deacetylasesmetabolismglioma cellsmiRscancerInhibitorinhibitorinhibit

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