L-Pyroglutamic acid

Name: L-Pyroglutamic acid
Brand: MedChemExpress
SKU: HY-76082
Rating: 4.5 (1 reviews)

Cat. No.: HY-76082 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.

For research use only. We do not sell to patients.

L-Pyroglutamic acid Chemical Structure

CAS No. : 98-79-3

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 g	USD 25	In-stock	Estimated Time of Arrival: December 31
50 g	USD 40	In-stock	Estimated Time of Arrival: December 31
> 100 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of L-Pyroglutamic acid:

L-Pyroglutamic acid-d₅ Get quote
L-Pyroglutamic acid-¹³C₅ Get quote
L-Pyroglutamic acid sodium Get quote
L-Pyroglutamic acid (Standard) Get quote

1 Publications Citing Use of MCE L-Pyroglutamic acid

•Research Square Preprint. 2021 Aug.

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Biological Activity
Purity & Documentation
Customer Review

Description

L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

129.11

Formula

C₅H₇NO₃

CAS No.

98-79-3

Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)[C@H](CC1)NC1=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (774.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (774.53 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.7453 mL	38.7267 mL	77.4533 mL
5 mM	1.5491 mL	7.7453 mL	15.4907 mL
10 mM	0.7745 mL	3.8727 mL	7.7453 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (19.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (19.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (19.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 140 mg/mL (1084.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (247 KB) SDS (393 KB)

COA (248 KB) HNMR (255 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	7.7453 mL	38.7267 mL	77.4533 mL	193.6333 mL
	5 mM	1.5491 mL	7.7453 mL	15.4907 mL	38.7267 mL
	10 mM	0.7745 mL	3.8727 mL	7.7453 mL	19.3633 mL
	15 mM	0.5164 mL	2.5818 mL	5.1636 mL	12.9089 mL
	20 mM	0.3873 mL	1.9363 mL	3.8727 mL	9.6817 mL
	25 mM	0.3098 mL	1.5491 mL	3.0981 mL	7.7453 mL
	30 mM	0.2582 mL	1.2909 mL	2.5818 mL	6.4544 mL
	40 mM	0.1936 mL	0.9682 mL	1.9363 mL	4.8408 mL
	50 mM	0.1549 mL	0.7745 mL	1.5491 mL	3.8727 mL
	60 mM	0.1291 mL	0.6454 mL	1.2909 mL	3.2272 mL
	80 mM	0.0968 mL	0.4841 mL	0.9682 mL	2.4204 mL
	100 mM	0.0775 mL	0.3873 mL	0.7745 mL	1.9363 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.