2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase
  4. (S)-GNE-140

(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

For research use only. We do not sell to patients.

(S)-GNE-140 Chemical Structure

(S)-GNE-140 Chemical Structure

CAS No. : 2003234-64-6

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10 mM * 1 mL in DMSO
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10 mg USD 338 In-stock
50 mg USD 995 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-GNE-140:

(S)-GNE-140 Related Antibodies

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Description

(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

IC50 & Target

LDHA[1]
Molecular Weight

499.04

Formula

C25H23ClN2O3S2
CAS No.
Appearance

Solid

Color

White to gray

SMILES

O=C1N[C@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 14.43 mg/mL (28.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0038 mL 10.0192 mL 20.0385 mL
5 mM 0.4008 mL 2.0038 mL 4.0077 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0038 mL 10.0192 mL 20.0385 mL 50.0962 mL
5 mM 0.4008 mL 2.0038 mL 4.0077 mL 10.0192 mL
10 mM 0.2004 mL 1.0019 mL 2.0038 mL 5.0096 mL
15 mM 0.1336 mL 0.6679 mL 1.3359 mL 3.3397 mL
20 mM 0.1002 mL 0.5010 mL 1.0019 mL 2.5048 mL
25 mM 0.0802 mL 0.4008 mL 0.8015 mL 2.0038 mL
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(S)-GNE-140 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-GNE-1402003234-64-6Lactate DehydrogenaseLDHInhibitorinhibitorinhibit

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(S)-GNE-140
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