2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. β-Casomorphin, bovine

β-Casomorphin, bovine  (Synonyms: β-Casomorphin-7 (bovine); Bovine β-casomorphin-7)

Cat. No.: HY-P0179 Purity: 99.65%
SDS COA Handling Instructions Technical Support

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.

For research use only. We do not sell to patients.

β-Casomorphin, bovine Chemical Structure

β-Casomorphin, bovine Chemical Structure

CAS No. : 72122-62-4

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Based on 1 publication(s) in Google Scholar

Other Forms of β-Casomorphin, bovine:

β-Casomorphin, bovine Related Antibodies

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  • Customer Review

Description

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].

IC50 & Target

IC50: 14 μM (Opioid receptor)[1]
In Vitro

β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2].
β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2].
β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC[2].
β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Casomorphin, bovine Related Antibodies
In Vivo

β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley (SD) rats (200 g±10 g)[3]
Dosage: 7.5×10−6 mol/day/kg
Administration: Oral gavage; for 30 days
Result: Increased plasma insulin and decreased plasma glucagon of diabetic rats.
Molecular Weight

789.92

Formula

C41H55N7O9
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Pro-Phe-Pro-Gly-Pro-Ile
Sequence Shortening

YPFPGPI
SMILES

O=C(N(CCC1)[C@@H]1C(NCC(N(CCC2)[C@@H]2C(N[C@H](C(O)=O)[C@@H](C)CC)=O)=O)=O)[C@@H](NC([C@H](CCC3)N3C([C@@H](N)CC4=CC=C(O)C=C4)=O)=O)CC5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (63.30 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2660 mL 6.3298 mL 12.6595 mL
5 mM 0.2532 mL 1.2660 mL 2.5319 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (31.65 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

SDS (252 KB)

COA (250 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.2660 mL 6.3298 mL 12.6595 mL 31.6488 mL
5 mM 0.2532 mL 1.2660 mL 2.5319 mL 6.3298 mL
10 mM 0.1266 mL 0.6330 mL 1.2660 mL 3.1649 mL
15 mM 0.0844 mL 0.4220 mL 0.8440 mL 2.1099 mL
20 mM 0.0633 mL 0.3165 mL 0.6330 mL 1.5824 mL
25 mM 0.0506 mL 0.2532 mL 0.5064 mL 1.2660 mL
30 mM 0.0422 mL 0.2110 mL 0.4220 mL 1.0550 mL
40 mM 0.0316 mL 0.1582 mL 0.3165 mL 0.7912 mL
50 mM 0.0253 mL 0.1266 mL 0.2532 mL 0.6330 mL
60 mM 0.0211 mL 0.1055 mL 0.2110 mL 0.5275 mL
DMSO 80 mM 0.0158 mL 0.0791 mL 0.1582 mL 0.3956 mL
100 mM 0.0127 mL 0.0633 mL 0.1266 mL 0.3165 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Casomorphin, bovine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Casomorphin, bovine72122-62-4β-Casomorphin-7 (bovine) Bovine β-casomorphin-7Opioid ReceptoropioidpeptidemucinInhibitorinhibitorinhibit

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