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  4. a-Helical Corticotropin Releasing Factor (9-41)

a-Helical Corticotropin Releasing Factor (9-41) 

Cat. No.: HY-P3169
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α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo.

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a-Helical Corticotropin Releasing Factor (9-41) Chemical Structure

a-Helical Corticotropin Releasing Factor (9-41) Chemical Structure

CAS No. : 99658-03-4

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Description

α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[1][2].

In Vivo

α-Helical Corticotropin Releasing Factor (9-41) (10 μg; the third or lateral ventricle of the brain injection; once) significantly decreases plasma GH values[1].
α-Helical Corticotropin Releasing Factor (9-41) (100 ng/kg; i.c.v. once) affects rhlL-1/β-induced enhancement of the splenic sympathetic activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Sprague-Dawley rats[1]
Dosage: 10 μg
Administration: The third or lateral ventricle of the brain injection; 10 μg once
Result: Abolished the 10 min electroshocks-produced the decreasing of plasma GH levels by injected into the third or lateral ventricle of the brain 45 min before exposure to stress.
Animal Model: Adult Sprague-Dawley rats with immunity of endogenous somatostatin (SS)[1]
Dosage: 10 μg
Administration: Lateral ventricle brain injection; 10 μg once
Result: Showed no effect on plasma GH values in rats whose endogenous SS had been immunoneutralized, but did interfere with the stimulatory effect of GH-releasing factor (GRF).
Animal Model: Male Wistar rats with rhlL-1/β injection[2]
Dosage: 100 ng/kg
Administration: Intracerebroventricularly injection; 100 ng/kg once
Result: Completely blocked the rhlL-1/β-induced enhancement of the splenic sympathetic activity, but failed to alter the enhancement of nociceptive behaviors caused by rhlL-1/β.
Molecular Weight

3827.34

Formula

C166H273N45O54S2
CAS No.
Sequence Shortening

DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA
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References
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Keywords:

a-Helical Corticotropin Releasing Factor (9-41)99658-03-4CRFRCorticotropin-releasing Factor ReceptorCRHRplasma growth hormonesomatostatinGH-releasing factorrhlL-1/βratInhibitorinhibitorinhibit

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