2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. AC-261066

AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0.

For research use only. We do not sell to patients.

AC-261066 Chemical Structure

AC-261066 Chemical Structure

CAS No. : 870773-76-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Solution
10 mM * 1 mL in DMSO USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 145 In-stock
25 mg USD 290 In-stock
50 mg USD 470 In-stock
100 mg USD 750 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AC-261066 Related Antibodies

Top Publications Citing Use of Products

View All RAR/RXR Isoform Specific Products:

View All Isoforms
RXRα RXRβ RXRγ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AC-261066 is a potent, orally available and isoform-selective retinoic acid beta2 (RARbeta2) receptor agonist, with a pEC50 of 8.0[1].

IC50 & Target

pEC50: 8.0 (RARbeta2)[1]
Cellular Effect
Cell Line Type Value Description References
COS-7 EC50
12 nM
Compound: AC 261066
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
Transactivation of GAL4-fused mouse RARbeta-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
[PMID: 30792038]
COS-7 EC50
5.8 nM
Compound: AC 261066
Transactivation of GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
Transactivation of GAL4-fused mouse RARgamma-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
[PMID: 30792038]
COS-7 EC50
70 nM
Compound: AC 261066
Transactivation of GAL4-fused mouse RARalpha-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
Transactivation of GAL4-fused mouse RARalpha-LBD expressed in COS-7 cells after 24 hrs by bright-Glo reagent based assay
[PMID: 30792038]
In Vitro

AC-261066 exhibits good oral bioavailability in rats (F oral = 52%)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AC-261066 Related Antibodies
Molecular Weight

353.41

Formula

C17H20FNO4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)C1=CC=C(C2=NC(OCCOCCCC)=C(C)S2)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (141.48 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8296 mL 14.1479 mL 28.2957 mL
5 mM 0.5659 mL 2.8296 mL 5.6591 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8296 mL 14.1479 mL 28.2957 mL 70.7394 mL
5 mM 0.5659 mL 2.8296 mL 5.6591 mL 14.1479 mL
10 mM 0.2830 mL 1.4148 mL 2.8296 mL 7.0739 mL
15 mM 0.1886 mL 0.9432 mL 1.8864 mL 4.7160 mL
20 mM 0.1415 mL 0.7074 mL 1.4148 mL 3.5370 mL
25 mM 0.1132 mL 0.5659 mL 1.1318 mL 2.8296 mL
30 mM 0.0943 mL 0.4716 mL 0.9432 mL 2.3580 mL
40 mM 0.0707 mL 0.3537 mL 0.7074 mL 1.7685 mL
50 mM 0.0566 mL 0.2830 mL 0.5659 mL 1.4148 mL
60 mM 0.0472 mL 0.2358 mL 0.4716 mL 1.1790 mL
80 mM 0.0354 mL 0.1768 mL 0.3537 mL 0.8842 mL
100 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7074 mL
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AC-261066 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-261066870773-76-5AC261066AC 261066RAR/RXRRetinoic acid receptorsRetinoid X receptorsisoform-selectiveRARbeta2Inhibitorinhibitorinhibit

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