2. Neuronal Signaling
  3. Amyloid-β
  4. Aducanumab

Aducanumab  (Synonyms: BIIB037)

Cat. No.: HY-P9967 Purity: 99.25%
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Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

CAS No. : 1384260-65-4

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Aducanumab Related Antibodies

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Description

Aducanumab (BIIB037) is a human monoclonal antibody that selectively targets aggregated amyloid-beta (Aβ). Aducanumab shows brain penetration, and can be used for Alzheimer's disease (AD) research[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vivo

Aducanumab (30 mg/kg, i.p., single dose) binds all morphological types of brain Aβ plaques in 22-month-old Tg2576 transgenic mice, including diffuse Aβ deposits and compact Aβ plaques[1].
Aducanumab (0.3-30 mg/kg, i.p., weekly, 6 months) reduces soluble and insoluble Aβ in a dose-dependent manner in 9.5- to 15.5-month-old Tg2576 transgenic mice[1].
Aducanumab (10 mg/kg, i.p., weekly, 6 months) restores intracellular calcium to control levels in 18-month-old Tg2576 mice[2].
Aducanumab (0.4-1 mg/mL, ICV, 20 min) leads to rapid decrease in amyloid burden, plaque clearance in Tg2576 mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 9.5- to 15.5-month-old Tg2576 transgenic mice [1]
Dosage: 0.3-30 mg/kg
Administration: Intraperitoneal injection (i.p.), weekly, 6 months
Result: Increased recruitment of Iba-1-positive microglia to Aβ plaques.
Animal Model: 18-month-old Tg2576 mice[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), weekly, 6 months
Result: Restored neurite baseline calcium to control levels.
Decreased the number of neurites with elevated levels of calcium after 2 weeks.
Decreased the percentage of cell bodies with calcium overload.
Restored the levels of VILIP and SERCA to control levels.
Increased the cell numbers of NR1 and NR2A.
Animal Model: 22-month-old transgenic Tg2576 mice[2]
Dosage: 0.4-1 mg/mL
Administration: Intracerebroventricular injection (ICV), 20 min
Result: Decreased the number of amyloid plaque.
Decreased the size of the remaining individual plaques.
Reduced amyloid plaque burden.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Aducanumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 99.25%

SDS (251 KB)

COA (231 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Aducanumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aducanumab1384260-65-4BIIB037BIIB 037BIIB-037Amyloid-ββ-amyloid peptideAβAbetaamyloid betahuman monoclonal antibodyAlzheimer's diseasebrain penetrationInhibitorinhibitorinhibit

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