2. Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
  4. Alpha-Naphthoflavone

Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis.

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Alpha-Naphthoflavone Chemical Structure

Alpha-Naphthoflavone Chemical Structure

CAS No. : 604-59-1

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Based on 6 publication(s) in Google Scholar

Alpha-Naphthoflavone Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis[1][2][3][4].

IC50 & Target

Aromatase

 

In Vitro

Alpha-Naphthoflavone (0.01-100 μM, 5 min) induces vascular relaxation by inducing extracellular calcium inflow and NO formation[2].
Alpha-Naphthoflavone (0.01-100 μM, 48 h) can inhibit HeLa cell proliferation, block the G1/S phase, and increase p53 level and apoptosis[3].
Alpha-Naphthoflavone (5, 10, 20, 40 μM, 24 h) can protect HepG2 hepatocytes treated with oleic acid (OA)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alpha-Naphthoflavone Related Antibodies

Cell Proliferation Assay[3]

Cell Line: HeLa
Concentration: 0.01, 1, 10, 100 μM
Incubation Time: 6 days
Result: Decreased cell proliferation in a dose-dependent manner with IC50 value of 36.81 μM.

Apoptosis Analysis[3]

Cell Line: HeLa
Concentration: 50 μM
Incubation Time: 12, 24, 36 h
Result: Induced a mild but significant apoptosis rate.

Western Blot Analysis[3]

Cell Line: HeLa
Concentration: 50 μM
Incubation Time: 12, 24, 36 h
Result: Increased the level of p53 at 12 h.
In Vivo

Alpha-Naphthoflavone (80, 160 mg/kg/day, gavage for 4 weeks) has protective effects on NAFLD mice induced by high-fat diet (HFD)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HFD-induced mice model[4]
Dosage: 80, 160 mg/kg
Administration: i.g.
Result: Decreased the levels of AST, TG and TC.
Molecular Weight

272.30

Formula

C19H12O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (91.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6724 mL 18.3621 mL 36.7242 mL
5 mM 0.7345 mL 3.6724 mL 7.3448 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.54%

COA (254 KB) HNMR (253 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6724 mL 18.3621 mL 36.7242 mL 91.8105 mL
5 mM 0.7345 mL 3.6724 mL 7.3448 mL 18.3621 mL
10 mM 0.3672 mL 1.8362 mL 3.6724 mL 9.1811 mL
15 mM 0.2448 mL 1.2241 mL 2.4483 mL 6.1207 mL
20 mM 0.1836 mL 0.9181 mL 1.8362 mL 4.5905 mL
25 mM 0.1469 mL 0.7345 mL 1.4690 mL 3.6724 mL
30 mM 0.1224 mL 0.6121 mL 1.2241 mL 3.0604 mL
40 mM 0.0918 mL 0.4591 mL 0.9181 mL 2.2953 mL
50 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.8362 mL
60 mM 0.0612 mL 0.3060 mL 0.6121 mL 1.5302 mL
80 mM 0.0459 mL 0.2295 mL 0.4591 mL 1.1476 mL
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Alpha-Naphthoflavone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alpha-Naphthoflavone604-59-1Cytochrome P450Aryl Hydrocarbon ReceptorApoptosisCYPsAhRAromataseInhibitorHeLaHepG2HFD-induced mice modelinhibitorinhibit

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