2. NF-κB
  3. NF-κB
  4. ALPK1-IN-2

ALPK1-IN-2 (compound T001) is a potent ALPK1 (alpha-kinase 1) inhibitor, with an IC50 of 95 nM. ALPK1-IN-2 also inhibits NF-κB, with an IC50 of 1.31 μM.

For research use only. We do not sell to patients.

ALPK1-IN-2 Chemical Structure

ALPK1-IN-2 Chemical Structure

CAS No. : 2765633-68-7

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1 mg USD 152 In-stock
5 mg USD 380 In-stock
10 mg USD 600 In-stock
25 mg USD 1150 In-stock
50 mg USD 1880 In-stock
100 mg USD 2900 In-stock
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Based on 1 publication(s) in Google Scholar

ALPK1-IN-2 Related Antibodies

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View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

ALPK1-IN-2 (compound T001) is a potent ALPK1 (alpha-kinase 1) inhibitor, with an IC50 of 95 nM. ALPK1-IN-2 also inhibits NF-κB, with an IC50 of 1.31 μM[1].

IC50 & Target

IC50: 95 nM (ALPK1), 1.31 μM (NF-κB)[1]
Molecular Weight

416.44

Formula

C20H18F2N4O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=CC=CC2=C1N=C(S2)NC(C3=C(C=C(C=C3F)N4CC5CC(N5)C4)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMF : 50 mg/mL (120.07 mM; Need ultrasonic)

DMSO : 50 mg/mL (120.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4013 mL 12.0065 mL 24.0131 mL
5 mM 0.4803 mL 2.4013 mL 4.8026 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMSO 1 mM 2.4013 mL 12.0065 mL 24.0131 mL 60.0327 mL
5 mM 0.4803 mL 2.4013 mL 4.8026 mL 12.0065 mL
10 mM 0.2401 mL 1.2007 mL 2.4013 mL 6.0033 mL
15 mM 0.1601 mL 0.8004 mL 1.6009 mL 4.0022 mL
20 mM 0.1201 mL 0.6003 mL 1.2007 mL 3.0016 mL
25 mM 0.0961 mL 0.4803 mL 0.9605 mL 2.4013 mL
30 mM 0.0800 mL 0.4002 mL 0.8004 mL 2.0011 mL
40 mM 0.0600 mL 0.3002 mL 0.6003 mL 1.5008 mL
50 mM 0.0480 mL 0.2401 mL 0.4803 mL 1.2007 mL
60 mM 0.0400 mL 0.2001 mL 0.4002 mL 1.0005 mL
80 mM 0.0300 mL 0.1501 mL 0.3002 mL 0.7504 mL
100 mM 0.0240 mL 0.1201 mL 0.2401 mL 0.6003 mL
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ALPK1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALPK1-IN-22765633-68-7NF-κBNuclear factor-κBNuclear factor-kappaBbenzothiazolequinolineHEK293 cellsanticanceranti-inflammationInhibitorinhibitorinhibit

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